Genipin derivatives and uses thereof
View Patent ↗Genipin derivatives and pharmaceutical compositions thereof that inhibit the activity of uncoupling protein-2 (UCP2) and are useful in treating deficient first-phase insulin secretion, non-insulin dependent diabetes mellitus, and ischemia in a mammal are disclosed.
1. A compound represented by a structural formula selected from
2. A pharmaceutical composition, comprising a pharmaceutically acceptable carrier and a compound of claim 1 .
3. A compound represented by the following structural formula:
4. A pharmaceutical composition, comprising a pharmaceutically acceptable carrier and a compound of claim 3 .
5. A compound represented by the following structural formula:
6. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of claim 5 .
7. A compound represented by the following structural formula:
8. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of claim 7 .
9. A compound represented by a structural formula selected from:
10. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of claim 9 .