Tamponade compositions and methods for retinal repair
View Patent ↗Described herein are methods of repairing retinal tissue using resorbable tamponade compositions that are heavier than aqueous humor and contain one or more glysosaminoglycans.
1. A method of treating a break in retinal tissue in a subject, the method comprising:
removing the vitreous humor from the vitreous cavity of the subject's eye; and
administering into the vitreous cavity an amount of a tamponade composition sufficient to cover the retinal detachment or the macular hole, wherein the tamponade composition comprising:
(a) a non-toxic, resorbable liquid that is denser than aqueous humor, wherein said liquid is deuterium-containing heavy water, and
(b) at least one glycosaminoglycan selected from the group consisting of hyaluronic acid, chondroitin sulfate, keratan sulfate, keratan sulfate II, heparan sulfate, and dermatan sulfate and a non-toxic, resorbable liquid that is denser than aqueous humor.
2. The method of claim 1 , wherein the tamponade composition comprises about 0.05 mg of the glycosaminoglycan per milliliter of the composition.
3. The method of claim 2 , wherein the glycosaminoglycan is hyaluronic acid.
4. The method of claim 3 , wherein the tamponade composition further comprises about 0.05 mg of chondroitin sulfate per milliliter of the composition.
5. The method of claim 1 , wherein the tamponade composition comprises from about 0.9 mg to 5 mg of the glycosaminoglycan per milliliter of the composition.
6. The method of claim 5 , wherein the glycosaminoglycan is hyaluronic acid.
7. The method of claim 6 , wherein the tamponade composition further comprises about 0.05 mg of chondroitin sulfate per milliliter of the composition.
8. The method of claim 1 , wherein the subject has (i) a superior retinal detachment and (ii) an inferior retinal detachment or a macular hole, and the method further comprises administering a gaseous tamponade agent to the vitreous cavity of the eye.