IP Library › Granted Patent US 7,659,312
Granted Patent B2
US 7,659,312 · App. 11/757,191 · Granted Feb 9, 2010

Inhibitors of Aquaporin 4, methods and uses thereof

Assignee: Niigata University
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Quick Facts
Patent No.
US 7,659,312
App. No.
11/757,191
Granted
Feb 9, 2010
Kind
B2
Abstract

This invention relates an inhibitory modulator of AQP4 protein regarding its transmembrane water transport properties, wherein the modulator selectively binds to the AQP4 protein, and inhibits AQP4 mediated water transport.

Claims (3)

1. An inhibitory modulator of AQP4 protein, wherein the modulator binds to the AQP4 protein, and inhibits AQP4 mediated water transport, and wherein said modulator is represented by the following formula:

or a pharmaceutically acceptable salt thereof.

2. A method for inhibiting AQP4 mediated water transport, comprising dosing the inhibitory modulator of AQP4 according to claim 1 , and binding the modulator to the AQP4 protein.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 4, 2007
From: NAKADA, TSUTOMU; HUBER, VINCENT J.
To: NIIGATA UNIVERSITY
Reel/Frame 019372/0694 →
Priority Claims (1)
JP 2006-154063 · Jun 1, 2006 · national
Continuity (1)
Related Publication 20070281978A1 · Dec 6, 2007