Topical compositions comprising benfotiamine and pyridoxamine
The present invention provides a composition comprising an effective amount of benfotiamine and an effective amount of pyridoxamine in a suitable vehicle for topical application. The present compositions are useful in improving the appearance of aged skin characterized by wrinkles, loss of elasticity, and hyperpigmentation caused by chronoaging and/or photoaging of skin, by inhibiting particularly skin damage resulting from reactive carbonyl species (RCS), glycation of skin proteins, formation of advanced glycation endproducts (AGEs) and formation of advanced lipoxidation endproducts (ALEs).
1. A topical dermatological formulation selected from the group consisting of a composition having the active components:
3% Pyridoxamine,
2% Benfotiamine,
1% Carnosine,
1% Astaxanthin,
0.5% Tocotrienol,
0.5% Tocopherol,
0.5% grape proanthocyanidin, and
0.05% ethylenediamine tetracetic acid;
a composition having the active components:
0.5% Pyridoxamine,
0.2% Benfotiamine,
1% billberry anthocyanin,
1% shark derived glycosaminoglycan,
2% green tea polyphenol,
0.5% tocopherol, and
1% α G-rutin,
a composition having the active components:
1% Pyridoxamine,
1% Benfotiamine,
0.5% Lutein,
3% Tetrahexyldecylascorbate,
0.5% Lycopene,
0.1% coenzyme Q10, and
0.5% Curcumine,
a composition having the active components:
3% Pyridoxamine,
3% Benfotiamine,
3% Carnosine,
0.01% Carnosol,
0.1% Aminoguanidine,
0.1% Tocotrienol,
0.5% Tocopherol,
0.5% retynyl palmitate, and
1% tetrahydrocurcuminoid,
a composition having the active components:
1% Pyridoxamine,
1% Benfotiamine,
1% Pyridoxanine,
1% pyridoxal 5′-phosphate,
1% pyridoxamine 5′-phosphate, and
1% thiamine, and
a composition having the active components:
1% Pyridoxamine,
1% Benfotiamine,
1% Pyruvate,
1% Biotin, and
1% Quercetin.
2. The topical dermatological formulation of claim 1 , having the active components:
3% Pyridoxamine,
2% Benfotiamine,
1% Carnosine,
1% Astaxanthin,
0.5% Tocotrienol,
0.5% Tocopherol,
0.5% grape proanthocyanidin, and
0.05% ethylenediamine tetracetic acid.
3. The topical dermatological formulation of claim 1 , having the active components:
0.5% Pyridoxamine,
0.2% Benfotiamine,
1% billberry anthocyanin,
1% shark derived glycosaminoglycan,
2% green tea polyphenol,
0.5% tocopherol, and
1% α G-rutin.
4. The topical dermatological formulation of claim 1 , having the active components:
1% Pyridoxamine,
1% Benfotiamine,
0.5% Lutein,
3% Tetrahexyldecylascorbate,
0.5% Lycopene,
0.1% coenzyme Q10, and
0.5% Curcumine.
5. The topical dermatological formulation of claim 1 , having the active components:
3% Pyridoxamine,
3% Benfotiamine,
3% Carnosine,
0.01% Carnosol,
0.1% Aminoguanidine,
0.1% Tocotrienol,
0.5% Tocopherol,
0.5% retynyl palmitate, and
1% tetrahydrocurcuminoid.
6. The topical dermatological formulation of claim 1 , having the active components:
1% Pyridoxamine,
1% Benfotiamine,
1% Pyridoxanine,
1% pyridoxal 5′-phosphate,
1% pyridoxamine 5′-phosphate, and
1% thiamine.
7. The topical dermatological formulation of claim 1 , having the active components:
1% Pyridoxamine,
1% Benfotiamine,
1% Pyruvate,
1% Biotin, and
1% Quercetin.
8. The topical dermatological formulation of claim 1 , wherein the formulation is placed in a container, said container being airtight, the container substantially blocks light between 450 and 720 nm, or a combination thereof.
9. The topical dermatological formulation of claim 1 , wherein the components are encapsulated in liposomes or nanosomes.
10. A method of inhibiting the formation of advanced glycation endproducts (AGEs) in the skin, said method comprising topically applying to skin areas to be treated a composition according to claim 1 .
11. The method of claim 10 , further comprising orally administering an AGE inhibitor.
12. The method of claim 10 , wherein inhibition of the formation of advanced glycation endproducts occurs after or concurrently with the oral ingestion or topical application of a sugar, amino acid, or vitamin C derivative, wherein the sugar, amino acid, or vitamin C derivative is either prone to glycation or has an oxidation product that is prone to glycation.
13. The method of claim 10 , wherein the composition is in the form of a makeup product.
14. The method of claim 10 , wherein inhibiting the formation of advanced glycation endproducts comprises reducing the advanced glycation endproduct formation in the skin by at least 50%.
15. The method of claim 10 , further comprising inhibiting the formation of advanced lipoxidation end products.