Dialkylphenyl compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
This invention relates to compounds of formula I: wherein R 1 and R 2 are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention also relates to pharmaceutical compositions and combinations comprising such compounds, processes and intermediates for preparing such compounds, and methods of using such compound to, for example, treat pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.
1. A method of producing bronchodilation in a mammal, the method comprising administering to the mammal a bronchodilation-producing amount of a compound of formula I:
wherein R 1 is methyl or ethyl; R 2 is methyl or ethyl; or a pharmaceutically acceptable salt or stereoisomer thereof.
2. The method of claim 1 , wherein the compound has formula II:
wherein R 1 is methyl or ethyl; R 2 is methyl or ethyl; or a pharmaceutically acceptable salt thereof.
3. The method of claim 1 , wherein the compound has formula IIa:
or a pharmaceutically acceptable salt thereof.
4. The method of claim 3 , wherein the compound or the salt thereof is administered by inhalation.
5. The method of claim 3 , wherein the compound or the salt thereof is in micronized form.
6. A method of treating chronic obstructive pulmonary disease in a patient, the method comprising administering to the patient a compound of formula I:
wherein R 1 is methyl or ethyl; R 2 is methyl or ethyl; or a pharmaceutically acceptable salt or stereoisomer thereof.
7. The method of claim 6 , wherein the compound has formula II:
wherein R 1 is methyl or ethyl; R 2 is methyl or ethyl; or a pharmaceutically acceptable salt thereof.
8. The method of claim 6 , wherein the compound has formula IIa:
or a pharmaceutically acceptable salt thereof.
9. A method of treating asthma in a patient, the method comprising administering to the patient a compound of formula I:
wherein R 1 is methyl or ethyl; R 2 is methyl or ethyl; or a pharmaceutically acceptable salt or stereoisomer thereof.
10. The method of claim 9 , wherein the compound has formula II:
wherein R 1 is methyl or ethyl; R 2 is methyl or ethyl; or a pharmaceutically acceptable salt thereof.
11. The method of claim 9 , wherein the compound has formula IIa:
or a pharmaceutically acceptable salt thereof.