Method for fixing an implant, fixing member for the implant and implant composite
View Patent ↗A fixing member for an implant which comprises a tube or a pillar made of an hydroxyapatite ceramics at least one part of which is a ceramics porous article consisting essentially of a hydroxyapatite formed by agitation foaming, in which a number of approximately spherical pores mutually contact having pore structures communicated three-dimensionally opened at the contact area and having an averaged porosity of from 65% to 85%. A method for fixing an implant comprising a step of inserting an implant whose at least one part of the periphery is integrated with a hydroxyapatite ceramics into an implant insertion site of an alveolar bone or a gnathic bone. A method for fixing an implant, a fixing member for the implant and an implant composite in order to reinforce an implant insertion site by compensating or regenerating an alveolar bone or a gnathic bone on an implant treatment in dentistry or in oral surgery is obtained.
1. A dental implant fixing member, which is adapted to be inserted in an alveolar bone or a gnathic bone, said fixing member comprising:
a tube made of a hydroxyapatite ceramic, wherein at least a portion thereof is porous, the tube:
(i) consisting essentially of a hydroxyapatite formed by agitation foaming, in which tube a number of approximately spherical pores mutually contact, open at the contact area, and communicate three-dimensionally; and
(ii) having an average porosity of from 65% to 85%, an average pore diameter of between 150 μm and 600 μm, an average opening diameter of the three-dimensionally communicated pores at the contact area of at least 30 μm; and
a pillar which is a ceramic porous article consisting essentially of a hydroxyapatite formed by agitation foaming, in which pillar a plurality of approximately spherical pores mutually contact, open at the contact area, and communicate three-dimensionally, wherein the average porosity of the pillar is greater than the average porosity of the tube, wherein the pillar is disposed inside the tube in a manner that a peripheral surface of the pillar is surrounded by at least 70% of the tube, and wherein a cavity is provided in the fixing member so as to fix the implant therein.
2. The fixing member for an implant according to claim 1 , wherein mesenchymal stem cells, bone marrow cells or osteoblast cells are introduced into said tube or said pillar consisting essentially of the hydroxyapatite.
3. The fixing member for an implant according to claim 1 , wherein Platelet Rich Plasma (PRP) is introduced into said tube or said pillar consisting essentially of the hydroxyapatite.
4. The fixing member for an implant according to claim 2 , wherein Platelet Rich Plasma (PRP) is introduced into said tube or said pillar consisting essentially of the hydroxyapatite.
5. The fixing member for an implant according to claim 1 , wherein one or more of Platelet Derived Growth Factor (PDGF), Fibroblast Growth Factor (FGF), Transforming Growth Factor-beta (TGF-β), Hepatocyte Growth Factor (HGF), Bone Morphogenetic Protein (BMP), Vascular Endothelial Growth Factor (VEGF) and Enamel Matrix Derivative is introduced into said tube or said pillar consisting essentially of the hydroxyapatite.
6. The fixing member for an implant according to claim 1 , wherein a cross-sectional area perpendicular to the axial direction of said fixing member for the implant is from 1.5 times to 50 times as large as a cross-sectional area perpendicular to the axial direction of said implant.