85kDa neisserial antigen
An 85 kDa antigen from Neisseria meningitidis and Neisseria gonorrhoeae has been cloned, sequenced and expressed. The antigen is common to diverse strains, serogroups and serotypes of N. meningitidis , and also to N. gonorrhoeae, N. polysaccharia and N. lactamica . The protein sequences of N. meningitidis (serogroups A and B) and N. gonorrhoeae are highly homologous.
1. An isolated oligopeptide consisting of
the amino acid sequence comprising SEQ ID NO:89.
2. A composition comprising the oligopeptide of claim 1 , and a pharmaceutically acceptable vehicle.
3. The composition of claim 2 , further comprising one or more immunogenic components selected from the group consisting of (a) a protective antigen against Neisseria meningitidis serogroup B; (b) a protective antigen against Neisseria gonorrhoeae ; (c) a protective antigen against Neisseria meningitidis serogroup A; (d) a protective antigen against Neisseria meningitidis serogroup C; (e) a protective antigen against Neisseria meningitidis serogroup Y; (f) a protective antigen against Neisseria meningitidis serogroup W; (g) a protective antigen against Haemophilus influenzae ; (h) a protective antigen against pneumococcus; (i) a protective antigen against diphtheria; (j) a protective antigen against tetanus; (k) a protective antigen against whooping cough; (l) a protective antigen against Helicobacter pylori ; (m) a protective antigen against polio; and (n) a protective antigen against hepatitis B virus.