Process of preparing arylethanoldiamines
An improved process for preparing arylethanoldiamines is described. Compounds of this type are known to be useful as agonists at atypical beta-adrenoceptors (also known as beta-3-adrenoceptors).
1. A compound of Formula (IV):
or a salt thereof wherein:
R 2 represents hydrogen or C 1-6 alkyl;
R 3 represents hydrogen or C 1-6 alkyl;
L represents halogen;
R 4 represents a group (W):
wherein A represents an aryl; R 5 represents cyano or —CO 2 R 8 ; R 6 and R 7 independently represent hydrogen, C 1-6 alkyl, —CO 2 R 8 , cyano, halogen, trifluoromethyl or C 1-6 alkoxy; each R 12 independently represents substituents selected from: C 1-6 alkyl, halogen, trifluoromethyl and C 1-6 alkoxy, and n represents an integer from 0-4;
R 8 and R 9 independently represent C 1-6 alkyl; and
R 11 represents C 1-6 alkyl or aryl optionally substituted by C 1-6 alkyl or halogen.
2. The compound of Formula (IV) according to claim 1 wherein
R 2 is hydrogen;
R 3 is hydrogen;
R 4 is W
R 5 is —CO 2 R 8 ;
R 6 and R 7 are both hydrogen;
R 11 represents methyl; and
n is 0.
3. The compound according to claim 1 , wherein said compound has the formula: