Crystalline form of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((
The invention relates to a crystalline form of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S) -tetrahydrofuran-3-yloxy)-benzyl]-benzene, to a method for the preparation thereof, as well as to the use thereof for preparing medicaments.
1. The crystalline form of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-(S)-tetrahydrofuran-3-yloxy)-benzyl]-benzene having an X-ray diffraction pattern that comprises peaks at 18.84, 20.36 and 25.21 degrees 2θ±0.05 degrees 2θ, wherein said X-ray powder diffraction is made using CuK α1 radiation.
2. The crystalline form according to claim 1 , wherein the X-ray powder diffraction pattern further comprises peaks at 14.69, 19.16 and 19.50 degrees 2 ⊖±0.05 degrees 2 ⊖, wherein said X-ray powder diffraction pattern is made using CuK α1 radiation.
3. 1-Chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, wherein at least 50% of said 1-Chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]benzene is present in the form of the crystalline form in accordance with claim 1 .
4. A pharmaceutical composition comprising the crystalline form in accordance with claim 1 .
5. A pharmaceutical composition comprising the crystalline form in accordance with claim 2 .
6. A method for making the crystalline form in accordance with claim 1 , said method comprising the following steps:
(a) dissolving 1-chloro-4-(β-D-glucopyranos-1-yl)-2-]4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-benzene in a solvent or a mixture of solvents to form a saturated or nearly saturated solution;
(b) storing the solution to precipitate the crystalline form in accordance with claim 2 out of solution and thus to yield a suspension;
(c) isolating the precipitate from the suspension; and
(d) drying the precipitate until any excess of said solvent or mixture of solvents has been removed.
7. A method for making the crystalline form in accordance with claim 2 , said method comprising the following steps:
(a) dissolving 1-chloro-4-(β-D-glucopyranos-1-yl)-2-]4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-benzene in a solvent or a mixture of solvents to form a saturated or nearly saturated solution;
(b) storing the solution to precipitate the crystalline form in accordance with claim 3 out of solution and thus to yield a suspension;
(c) isolating the precipitate from the suspension; and
(d) drying the precipitate until any excess of said solvent or mixture of solvents has been removed.