Granted Patent
B2
US 7,723,536 · App. 12/072,730 · Granted May 25, 2010
Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof
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Abstract
Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.
Claims (9)
1. A compound of formula:
wherein:
R 6 is H or C 1 -C 10 alkyl;
R 7 and R 8 are independently C 1 -C 10 alkyl;
R 9 is an acid labile protecting group;
R 18 is C 6 -C 14 aryl; and
X is halogen.
2. The compound of claim 1 of formula:
wherein TBS is tert-butyldimethylsilyl and Ph is phenyl.
Assignments (3)
CONFIRMATORY LICENSE
Recorded Nov 9, 2022
From: UNIVERSITY OF PENNSYLVANIA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 061902/0149 →
CONFIRMATORY LICENSE
Recorded Apr 22, 2021
From: UNIVERSITY OF PENNSYLVANIA
To: NIH - DEITR
Reel/Frame 056009/0489 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 2, 2009
From: SMITH, AMOS B., III; BEAUCHAMP, THOMAS J.; LAMARCHE, MATTHEW J.; QIU, YUPING; KAUFMAN, MICHAEL D.; ARIMOTO, HIROKAZU; JONES, DAVID R.; KOBAYASHI, KAORU
To: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Reel/Frame 022495/0037 →
Continuity (7)