Alpha-ketoglutarates of active ingredients and compositions containing same
View Patent ↗Novel stable and pharmacologically acceptable salts of L-carnitine and lower alkanoyl L-carnitines with alpha-ketoglutaric acid are disclosed as well as the compositions useful as dietary and dietetic supplements, nutraceuticals or drugs containing same.
1. An alpha-ketoglutarate salt of L-carnitine or a lower alkanoyl L-carnitine in a ratio of one part lower alkanoyl L-carnitine to one part alpha-ketoglutaric anion and of the formula
wherein:
A − is the alpha-ketoglutarate anion; and
R is hydrogen or a straight- or branched-chain lower alkanoyl having 2-5 carbon atoms.
2. The alpha-ketoglutarate of claim 1 , wherein R is an alkanoyl selected from the group consisting of acetyl, propionyl, valeryl and isovaleryl.
3. L-carnitine alpha-ketoglutarate.
4. Acetyl L-carnitine alpha-ketoglutarate.
5. Propionyl L-carnitine alpha-ketoglutarate.
6. Valeryl L-carnitine alpha-ketoglutarate.
7. Isovaleryl L-carnitine alpha-ketoglutarate.
8. A pharmaceutical composition comprising:
(a) an effective amount of a compound of claim 1 ; and
(b) a pharmacologically acceptable excipient.
9. The composition of claim 8 , wherein the alpha-ketoglutarate is selected from the group consisting of:
L-carnitine alpha-ketoglutarate;
acetyl L-carnitine alpha-ketoglutarate;
propionlyl L-carnitine alpha-ketoglutarate;
valeryl L-carnitine alpha-ketoglutarate; and
isovaleryl L-carnitine alpha-ketoglutarate.