IP Library › Granted Patent US 7,728,143
Granted Patent B2
US 7,728,143 · App. 11/245,561 · Granted Jun 1, 2010

Salt and crystalline forms thereof of a drug

Assignee: Abbott Laboratories
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Quick Facts
Patent No.
US 7,728,143
App. No.
11/245,561
Granted
Jun 1, 2010
Kind
B2
Abstract

A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.

Claims (7)

1. D-Glucitol, 1-deoxy-1-(methylamino)-, 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxyazetidin-1-yl)-4-oxo-3-quinolinecarboxylate trihydrate salt.

2. Crystalline D-glucitol, 1-deoxy-1-(methylamino)-, 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxyazetidin-1-yl)-4-oxo-3-quinolinecarboxylate salt characterized, when measured at about 25° C. with Cu—Kα radiation, by the powder diffraction pattern shown in FIG. 1 .

3. Crystalline D-glucitol, 1-deoxy-1-(methylamino)-, 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxyazetidin-1-yl)-4-oxo-3-quinolinecarboxylate trihydrate salt characterized, when measured at about 25° C. with Cu—Kα radiation, by the powder diffraction pattern shown in FIG. 2 .

4. A process for making D-glucitol, 1-deoxy-1-(methylamino)-, 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxyazetidin-1-yl)-4-oxo-3-quinolinecarboxylate salt comprising dehydrating D-glucitol, 1-deoxy-1-(methylamino)-, 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxyazetidin-1-yl)-4-oxo-3-quinolinecarboxylate trihydrate salt.

5. D-Glucitol, 1-deoxy-1-(methylamino)-, 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxyazetidin-1-yl)-4-oxo-3-quinolinecarboxylate salt prepared as described in claim 4 .

6. A process for making D-glucitol, 1-deoxy-1-(methylamino)-, 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxyazetidin-1-yl)-4-oxo-3-quinolinecarboxylate trihydrate salt by crystallization of D-glucitol, 1-deoxy-1-(methylamino)-, 1-(6-amino-3,5-difluoro-pyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxyazetidin-1-yl)-4-oxo-3-quinolinecarboxylate salt from water, with or without an alcohol.

7. D-Glucitol, 1-deoxy-1-(methylamino)-, 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxyazetidin-1-yl)-4-oxo-3-quinolinecarboxylate trihydrate salt prepared as described in claim 6 .

Assignments (5)
RELEASE OF SECURITY INTEREST Recorded Jan 5, 2018
From: SUCHARD SA LLC
To: MELINTA SUBSIDIARY CORP. (F/K/A MELINTA THERAPEUTICS, INC.)
Reel/Frame 044547/0939 →
SECURITY INTEREST Recorded Jun 28, 2017
From: MELINTA THERAPEUTICS, INC.
To: SUCHARD SA LLC
Reel/Frame 042854/0753 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 10, 2013
From: ABBOTT LABORATORIES
To: ABBVIE INC.
Reel/Frame 030185/0141 →
CORRECTIVE ASSIGNMENT TO CORRECT THE <APPLICATION NUMBER> PREVIOUSLY RECORDED ON REEL 018468 FRAME 0157. ASSIGNOR(S) HEREBY CONFIRMS THE CORRECTION OF <APPLICATION NUMBER> FROM <11/332,020> TO <11/245,561>. Recorded Apr 23, 2008
From: ZHANG, GEOFF G.Z.; BRADLEY, MICHAEL F.; BARNES, DAVID; HENRY, RODGER
To: ABBOTT LABORATORIES
Reel/Frame 020844/0912 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 1, 2006
From: ZHANG, GEOFF G.Z.; BRADLEY, MICHAEL F.; BARNES, DAVID; HENRY, RODGER
To: ABBOTT LABORATORIES
Reel/Frame 018468/0157 →
Continuity (2)
Provisional Application 6061733400 · Oct 8, 2004
Related Publication 20070043019A1 · Feb 22, 2007