Met kinase inhibitors

1. A compound having the following Formula I, II or III:

wherein:

X is —CR 12 ;

B is O;

A is —CR d ;

D is —CR e ;

l is 0 to 6;

n is 1;

each R 1 is independently H, halogen, cyano, NO 2 , OR 13 , NR 14 R 15 alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heterocycloalkyl, or substituted heterocycloalkyl;

R 3 , R 3b , R 4 , R 4a , R 4b , R 9 , R d and R e are independently H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, —CN, hydroxyl, halo, amino, alkylthio, alkoxy, aryl, heterocycloalkyl, aralkyl, alkylaryl, aminoalkylamino, or alkylaminoalkoxy;

R 3a is H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, —CN, hydroxyl, amino, alkylthio, alkoxy, aryl, heterocycloalkyl, aralkyl, alkylaryl, aminoalkylamino, or alkylaminoalkoxy;

R 5 , R 6 , R 7 , R 8 and R 12 are independently H, halogen, NO 2 , cyano, —OR 13 , —NR 14 R 15 , —CO 2 R 16 , —C(O)NR 14 R 15 , —SO 2 R 16 , —SO 2 NR 14 R 15 , —NR 14 SO 2 R 15 , —NR 14 C(O)R 15 , —NR 14 CO 2 R 15 , —CO(CH 2 ) 1 R 15 , —CONH(CH 2 ) 1 R 16 , alkylaminoalkyl, alkylaminoalkynyl, C 1 to C 6 alkyl, substituted C 1 to C 6 alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, hydroxyalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heterocycloalkyl, or substituted heterocycloalkyl;

R 11 is H, C 1 to C 6 alkyl, substituted C 1 to C 6 alkyl, C 3 to C 7 cycloalkyl, substituted C 3 to C 7 cycloalkyl, —OR 13 , aryl, substituted aryl, heteroaryl, substituted C 5 to C 14 heteroaryl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl, heterocycloalkyl, substituted heterocycloalkyl, heterocycloalkylalkyl or substituted heterocycloalkylalkyl;

R a , R 13 , R 14 , R 15 and R 16 are independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heterocycloalkyl, or substituted heterocycloalkyl;

R b and R c are independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl or taken together to form a carbocyclic or heterocyclic ring of 3 to 8 atoms.

2. The compound according to claim 1 wherein A is CH.

3. The compound according to claim 1 wherein D is CH.

4. The compound according to claim 1 wherein R 4a or R d is hydroxyl, halo, C 1 to C 4 alkyl, CN, alkylthio, alkoxy, phenyl, amino, heterocycloalkyl, aminoalkylamino and alkylaminoalkoxy.

5. The compound according to claim 1 wherein R 3a is phenyl.

6. The compound according to claim 1 wherein R 3 is benzyl.

7. The compound according to claim 1 wherein at least one of R 6 and R 7 is —OH, —OCH 3 , or —OCH 2 piperidine.

8. The compound according to claim 1 having Formula I, wherein R 1 is F, R 3a is phenyl, R 4a is H, and at least one of R 6 or R 7 is —OH, —OCH 3 , or OCH 2 piperidine.

9. The compound according to claim 1 having Formula III wherein R 1 is F, R 3 is benzyl, R 4 is H, and at least one of R 6 and R 7 is —OCH 3 .

10. A pharmaceutical composition comprising a compound according to claim 1 in a pharmaceutically acceptable carrier.

11. A compound selected from the group consisting of:

N-(4-(6,7-Dimethoxyquinolin-4-yloxy)-3-fluorophenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide;

N-(3-Fluoro-4-(7-hydroxy-6-methoxyquinolin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide;

N-(3-Fluoro-4-(6-methoxy-7-(piperidin-4-ylmethoxy)quinolin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide;

N-(3-Fluoro-4-(6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinolin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide;

N-(4-(6,7-Dimethoxyquinolin-4-yloxy)-3-fluorophenyl)-6-(4-fluorophenyl)picolin-N-oxide-amide; and

5-Benzyl-N-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide.