Composition and method for preventing or treating a virus infection
The present invention provides multiple antigenic agents compositions and the use thereof to prevent or treat viral infections.
1. A multiple antigenic agent comprising:
(SEQ ID NO:1) wherein, R 1 is absent or a nucleic acid sequence; m is at least 1; n is at least 1; Xaa 1 is 0 to 1 amino acid residue comprising
or Gly; R 2 , R 3 and R 4 are
independently a B cell determinant, a T cell determinant, or targeting molecule; and R 5 is alanine.
2. The multiple antigenic agent of claim 1 , wherein when m is greater than 1, each R 2 can independently be a B cell determinant, a T cell determinant, or a targeting molecule; and when n is greater than 1, each R 3 can independently be a B cell determinant, a T cell determinant, or a targeting molecule.
3. The multiple antigenic agent of claim 1 , wherein the B cell determinant comprises the ectodomain of influenza matrix protein 2 or a homolog thereof.
4. A composition comprising the multiple antigenic agent of claim 1 and a pharmaceutically acceptable carrier.
5. The composition of claim 4 , wherein the composition further comprises an adjuvant.
6. The composition of claim 4 , wherein the composition comprises a vaccine.
7. The composition of claim 5 , wherein the composition comprises a vaccine.
8. A method for preventing or treating a viral infection comprising administering to a subject an effective amount of a composition of claim 4 to prevent or treat the signs or symptoms of a viral infection.
9. A method for preventing or treating a viral infection comprising administering to a subject an effective amount of a composition of claim 5 to prevent or treat the signs or symptoms of a viral infection.
10. A method for preventing or treating a viral infection comprising administering to a subject an effective amount of a composition of claim 6 to prevent or treat the signs or symptoms of a viral infection.
11. A method for preventing or treating a viral infection comprising administering to a subject an effective amount of a composition of claim 7 to prevent or treat the signs or symptoms of a viral infection.
12. The method of claim 8 , wherein the viral infection comprises influenza type A virus.
13. The method of claim 9 , wherein the viral infection comprises influenza type A virus.
14. The method of claim 10 , wherein the viral infection comprises influenza type A virus.
15. The method of claim 11 , wherein the viral infection comprises influenza type A virus.