Targeted delivery of botulinum toxin to the sphenopalatine ganglion
Botulinum toxin, among other presynaptic neurotoxins is used for the treatment and prevention of migraine and other headaches associated with vascular disorders. Presynaptic neurotoxins are delivered focally, targeting the sphenopalatine ganglion. Exemplary delivery is carried out by way of injection.
1. A method for reduction of headache pain in a mammal in need thereof comprising:
administering to a sphenopalatine ganglion, in a pharmaceutically safe form to a mammal, a therapeutically effective amount of a botutinum toxin thereby effecting reduction of headache pain in the mammal.
2. The method according to claim 1 , wherein the botulinum toxin is administered by injection.
3. The method according to claim 2 , wherein the botulinum toxin is selected from the group consisting of botulinum toxin type A, B, C 1 , D, L, F or G.
4. The method according to claim 3 wherein the botulinum toxin is botulinum toxin type A.
5. The method according to claim 2 wherein said administering step comprises the steps of:
identifying an injection site midway between the tragus of the ear and the outer cantus of the eye;
inserting a syringe at an angle of about 50-70 degrees relative to the vertical plane of the face;
stopping the forward motion of the syringe upon reaching the maxillary bone;
injecting the botulinum toxin at the sphenopalatine ganglion; and
withdrawing the syringe.
6. The method according to claim 5 wherein said botulinum toxin is injected in a discrete manner at a plurality of locations adjacent to the sphenopalatine ganglion.
7. The method according to claim 1 wherein said headache pain is associated with a headache selected from the group consisting of migraine, trigeminal autonomic cephalgia and headache caused by a vascular condition.
8. The method according to claim 1 wherein said administering step is performed bilaterally.
9. The method according to claim 1 wherein said administering step is performed unilaterally.
10. A method for reduction of headache pain in a mammal in need thereof comprising:
administering by injection to a sphenopalatine ganglion, in a pharmaceutically safe form to a mammal, a therapeutically effective amount of botulinum toxin type A, thereby effecting reduction of headache pain in the mammal.
11. The method according to claim 10 wherein said headache pain is associated with a headache selected from the group consisting of migraine, trigeminal autonomic cephalgia and headache caused by a vascular condition.
12. The method according to claim 10 wherein said administering step comprises the steps of:
identifying an injection site midway between the tragus of the ear and the outer cantus of the eye;
inserting a syringe at an angle of about 50-70 degrees relative to the vertical plane of the face;
stopping the forward motion of the syringe upon reaching the maxillary bone;
injecting the botulinum toxin type A at the sphenopalatine ganglion; and
withdrawing the syringe.
13. The method according to claim 12 wherein said botulinum toxin type A is injected a discrete manner at a plurality of locations adjacent to the sphenopalatine ganglion.
14. The method according to claim 10 wherein said administering step is performed bilaterally.
15. The method according to claim 10 wherein said administering step is performed unilaterally.