Method for providing medicament to tissue
A system for delivering medicaments to tissue including a delivery member and an optical fiber formed together into a unitary structure. The optical fiber has an inlet attached to a laser energy source and an outlet for emitting laser energy. The delivery member has an inlet attached to a medicament source and an outlet for injecting medicament. A handpiece is adapted to receive the ablating and injecting device in a controlled and movable relationship and may include at least one tissue stabilizing member thereon. In use, the distal end of the handpiece is placed against tissue to be ablated. The optical fiber is advanced into the tissue while emitting laser energy thereby ablating the tissue and forming a channel therein. During retraction, medicament may be injected into the channel or into the tissue surrounding the channel.
1. A method of delivering medicament to tissue while preventing medicament washout, comprising:
providing a medicament delivery catheter having a tissue engaging surface with at least one vacuum operated tissue stabilizer port;
providing access to a tissue surface;
advancing the catheter to the tissue surface;
positioning the tissue engaging surface proximate the tissue surface;
sealably engaging the tissue engaging surface to the tissue surface by activating a vacuum force through the tissue stabilizer port;
forming a sealed opening in the tissue surface;
delivering medicament through the sealed opening in the tissue surface; and
preventing the medicament from passing between the tissue engaging surface and the tissue surface to a location outside the sealed opening.
2. The method of claim 1 wherein the catheter comprises at least one vacuum port positioned radially about the tissue engaging surface and at least one vacuum lumen located within the catheter.
3. The method of claim 2 wherein the catheter comprises four vacuum ports positioned on the tissue engaging surface.
4. A method of delivering medicament to tissue while preventing medicament washout, comprising:
providing a medicament delivery catheter having a tissue engaging surface with a sealing balloon;
providing access to a tissue surface;
advancing the catheter to the tissue surface;
positioning the tissue engaging surface proximate the tissue surface;
sealably engaging the tissue engaging surface to the tissue surface by inflating the sealing balloon;
forming a sealed opening in the tissue surface;
delivering medicament through the sealed opening in the tissue surface; and,
preventing the medicament from passing between the tissue engaging surface and the tissue surface to a location outside of the sealed opening.
5. The method of claim 4 wherein forming a sealed opening in the tissue surface comprises maintaining the inflated balloon against the tissue surface while the opening is formed.
6. The method of claim 4 wherein the inflated balloon is maintained against the tissue opening while the medicament is delivered.