Optically enhanced chiral ionic liquids
The invention relates to the use of optically enhanced chiral ionic liquids, particularly for gas chromatography and as a reaction solvent. Specific optically enhanced chiral cationic liquids are described as is a class of optically enhanced chiral anionic liquids.
1. A method for identifying an optically enhanced chiral ionic liquid (OCIL) for enantiomeric resolution, the method comprising:
a. forming a stationary phase on a column comprising a test OCIL;
b. injecting a mixture of two or more chiral optical isomers into the column;
c. advancing a mobile phase comprising said optical isomers through the column;
d. detecting retention times of said optical isomers;
e. calculating ratio of retention times between two or more of said optical isomers (α-value); and
f. selecting an OCIL having an α-value greater than 1.00.
2. The method of claim 1 , wherein the α-value is in a range from about 1.01 to about 1.11, inclusive.
3. The method of claim 1 , wherein the mobile phase further comprises a carrier gas.
4. The method of claim 3 , wherein the carrier gas is helium with a flow rate of about 1.0 mL/min.
5. The method of claim 1 , wherein the mobile phase is present at a temperature in the range of about 100° C. to about 140° C., inclusive.
6. The method of claim 1 , wherein the injecting comprises split injection.
7. The method of claim 6 , wherein the detecting comprises flame ionization detection.
8. The method of claim 7 , wherein the split injection and the flame ionization detection are utilized with injection and detection temperatures of about 250° C.
9. The method of claim 1 , wherein the mobile phase further comprises helium with a flow rate of about 1.0 mL/min at a temperature in the range of about 100° C. to about 140° C., inclusive.
10. The method of claim 9 , wherein the injecting comprises split injection at a temperature of about 250° C., and the detecting comprises flame ionization detection at a temperature of about 250° C.