Spiroindolinone derivatives

1. A compound of the formula

wherein

X is Cl, F or Br,

X′ is hydrogen or F,

V is F, Cl or Br,

V′ is hydrogen or F,

Y is hydrogen, methyl, methoxy, F or Cl,

W is F, Cl, Br, I, ethynyl or isopropenyl,

A is O, NH, CH 2 , C(═O), C(═O)NH, NHC(═O) or NHS(═O) 2 ,

B is a bond or (CH 2 ) m CR 1 R 2 (CH 2 ) n ,

m=0 or 1,

n=0 or 1,

R 1 , R 2 are hydrogen or lower alkyl,

and in the case of R 1 and R 2 they may independently link to form a cyclic structure selected from a substituted or unsubstituted cycloalkyl,

provided that

if B is a bond, then R is selected from heterocycle, substituted heterocyle, heteroaryl, substituted heteroaryl, aryl or substituted aryl,

if B is not a bond, then R is selected from OR″, NR′R″, C(═O)NR′R″, NHC(═O)R″, NHS(═O) 2 R″, NHC(═O)NR′R″ or C(═O)NR′S(═O) 2 R″,

R′, R″ is independently selected from the group consisting of hydrogen, lower alkyl, aryl, lower alkenyl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycle, substituted heterocycle, cycloalkyl and substituted cycloalkyl with the proviso that R″ is not a hydrogen,

and in the case of R′ and R″ they may independently link to form a cyclic structure selected from substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl or substituted or unsubstituted heterocycle

and the pharmaceutically acceptable salts and enantiomers thereof.

2. The compound of claim 1 wherein X is Cl, X′ is hydrogen or F, A is O, V is F or Cl, V′ is hydrogen or F, Y is methyl, methoxyl, Cl or F, W is Cl, F or Br.

3. A compound of claim 1 selected from the group consisting of

racemic (2′S,3S,4′R)-6-chloro-4′-{5-chloro-2-[1-methyl-1-(1-methyl-piperidin-4-ylcarbamoyl)-ethoxy]-phenyl}-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(1-cyclobutylcarbamoyl-1-methyl-ethoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-{5-chloro-2-[1-(2-hydroxy-ethylcarbamoyl)-1-methyl-ethoxy]-phenyl}-2′-(5-fluoro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-4′-{2-[1-(2-acetylamino-ethylcarbamoyl)-1-methyl-ethoxy]-5-chloro-phenyl}-6-chloro-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

(2′S,3S,4′R)-6-chloro-4′-{5-chloro-2-[1-(S-2,3-dihydroxy-propylcarbamoyl)-1-methyl-ethoxy]-phenyl}-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-{5-chloro-2-[1-(2-methoxy-ethylcarbamoyl)-1-methyl-ethoxy]-phenyl}-2′-(5-fluoro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-{5-chloro-2-[1-(3-dimethylamino-propylcarbamoyl)-1-methyl-ethoxy]-phenyl}-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-{5-chloro-2-[1-methyl-1-(2-piperidin-1-yl-ethylcarbamoyl)-ethoxy]-phenyl}-2′-(5-fluoro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-4′-[5-bromo-2-(2-methanesulfonylamino-1,1-dimethyl-2-oxo-ethoxy)-phenyl]-6-chloro-2′-(5-fluoro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(1-methanesulfonylaminocarbonyl-cyclobutoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione and

racemic (2′S,3S,4′R)-6-chloro-4′-{5-chloro-2-[1-(4-fluoro-benzenesulfonylaminocarbonyl)-cyclobutoxy]-phenyl}-2′-(5-fluoro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione.

4. A pharmaceutical composition comprising a compound of the formula

wherein

X is Cl, F or Br,

X′ is hydrogen or F,

V is F, Cl or Br,

V′ is hydrogen or F,

Y is hydrogen, methyl, methoxy, F or Cl,

W is F, Cl, Br, I, ethynyl or isopropenyl,

A is O, NH, CH 2 , C(═O), C(═O)NH, NHC(═O) or NHS(═O) 2 ,

B is a bond or (CH 2 ) m CR 1 R 2 (CH 2 ) n ,

m=0 or 1,

n=0 or 1,

R 1 , R 2 are hydrogen or lower alkyl,

and in the case of R 1 and R 2 they may independently link to form a cyclic structure selected from a substituted or unsubstituted cycloalkyl,

provided that

if B is a bond, then R is selected from heterocycle, substituted heterocyle, heteroaryl, substituted heteroaryl, aryl or substituted aryl,

if B is not a bond, then R is selected from OR″, NR′R″, C(═O)NR′R″, NHC(═O)R″, NHS(═O) 2 R″, NHC(═O)NR′R″ or C(═O)NR′S(═O) 2 R″,

R′, R″ is independently selected from the group consisting of hydrogen, lower alkyl, aryl, lower alkenyl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycle, substituted heterocycle, cycloalkyl and substituted cycloalkyl with the proviso that R″ is not a hydrogen,

and in the case of R′ and R″ they may independently link to form a cyclic structure selected from substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl or substituted or unsubstituted heterocycle

and the pharmaceutically acceptable salts and enantiomers thereof together with a pharmaceutically acceptable carrier or excipient.

5. A compound of claim 1 selected from the group consisting of

chiral (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(2-methanesulfonylamino-1,1-dimethyl-2-oxo-ethoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-4′-[5-bromo-2-(3-methyl-oxetan-3-ylmethoxy)-phenyl]-6-chloro-2′-(5-chloro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-isopropenyl-2-(3-methyl-oxetan-3-ylmethoxy)-phenyl]-2′-(5-chloro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-2′-(5-chloro-2-methyl-phenyl)-4′-[5-ethynyl-2-(3-methyl-oxetan-3-ylmethoxy)-phenyl]-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-4′-[2-(1-tert-butoxycarbonyl-piperidin-4-yloxy)-5-chloro-phenyl]-6-chloro-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(4-piperidinyloxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-4′-[2-(1-acetyl-4-piperidinyloxy)-5-chloro-phenyl]-6-chloro-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(1-methanesulfonyl-4-piperidinyloxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(pyrimidin-2-yloxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(2,2-dimethyl-3-oxo-3-pyrrolidin-1-yl-propoxy)-phenyl]-2′-(5-fluoro-2-methylphenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(2-dimethylcarbamoyl-2-methyl-propoxy)-phenyl]-2′-(5-fluoro-2-methylphenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione and

racemic (2′R,3S,4′R)-6-chloro-4′-[5-chloro-2-{[(2-hydroxy-ethyl)-methyl-carbamoyl]-methoxy}-phenyl]-2′-[2,5-difluorophenyl]spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione.

6. A compound of claim 1 selected from the group consisting of

racemic (2′R,3S,4′R)-6-chloro-4′-[5-chloro-2-dimethylcarbamoylmethoxy-phenyl]-2′-(2,5-difluorophenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′R,3S,4′R)-6-chloro-4′-[5-chloro-2-(2-oxo-2-pyrrolidin-1-yl-ethoxy)-phenyl]-2′-(2,5-difluorophenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-bromo-2-(1-dimethylcarbamoyl-1-methyl-ethoxy)-phenyl]-2′-(5-chloro-2-methyl phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(1-dimethylcarbamoyl-1-methyl-ethoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

chiral (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(1-dimethylcarbamoyl-1-methyl-ethoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-4′-{2-[2-(4-acetyl-piperazin-1-yl)-1,1-dimethyl-2-oxo-ethoxy]-5-chloro-phenyl}-6-chloro-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-{5-chloro-2-[1-methyl-1-(2,2,2-trifluoro-ethylcarbamoyl)-ethoxy]-phenyl}-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-{5-chloro-2-[2-(4,4-difluoro-piperidin-1-yl)-1,1-dimethyl-2-oxo-ethoxy]-phenyl}-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

chiral (2′S,3S,4′R)-6-chloro-4′-{5-chloro-2-[2-(4,4-difluoro-piperidin-1-yl)-1,1-dimethyl-2-oxo-ethoxy]-phenyl}-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(3-methyl-oxetan-3-ylmethoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′R,3S,4′R)-6-chloro-4′-[5-chloro-2-(1-dimethylcarbamoyl-1-methyl-ethoxy)-phenyl]-2′-(2,5-difluoro-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione and

racemic (2′S,3S,4′R)-4′-[2-(2-amino-ethoxy)5-chloro-phenyl]-6-chloro-2′-(5-fluoro-2-methyl phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione.

7. A compound of claim 1 selected from the group consisting of

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(2-methanesulfonylamino-ethoxy)-phenyl]-2′-(5-fluoro-2-methyl phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-[2-(3,3-dimethyl-ureido)-ethoxy]-phenyl]-2′-(5-fluoro-2-methyl phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′R,3S,4′R)-6-chloro-4′-[5-chloro-2-(1-dimethylcarbamoyl-1-methyl-ethoxy)-phenyl]-2′-(2-fluoro-5chloro-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-2′-[5-bromo-2-(4-methoxycarbonyl-phenoxy)-phenyl]-6-chloro-4′-(3-chlorophenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-2′-[5-bromo-2-(4-methoxycarbonyl-phenoxy)-phenyl]-6-chloro-4′-(3-fluorophenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-4′-[5-bromo-2-(1-tert-butoxycarbonyl-piperidin-4-yloxy)-phenyl]-6-chloro-2′-(3-fluorophenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-4′-[5-bromo-2-(4-piperidinyloxy)-phenyl]-6-chloro-2′-(5-fluorophenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-4′-[2-(1-acetyl-4-piperidinyloxy)-5-bromo-phenyl]-6-chloro-2′-(3-fluorophenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-4′-[5-bromo-2-(1-methyl-4-piperidinyloxy)-phenyl]-6-chloro-2′-(3-fluorophenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-4′-[5-bromo-2-(1-tert-butoxycarbonyl-piperidin-4-yloxy)-phenyl]-6-chloro-2′-(3-chlorophenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-4′-[5-bromo-2-(4-piperidinyloxy)-phenyl]-6-chloro-2′-(5-chlorophenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione and

racemic (2′S,3S,4′R)-4′-[2-(1-acetyl-4-piperidinyloxy)-5-bromo-phenyl]-6-chloro-2′-(3-chlorophenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione.

8. A compound of claim 1 selected from the group consisting of

racemic (2′S,3S,4′R)-4′-[5-bromo-2-(1-methyl-4-piperidinyloxy)-phenyl]-6-chloro-2′-(3-chlorophenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

chiral (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(2-methanesulfonylamino-ethoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′R,3S,4′R)-6-chloro-2′-(2-chloro-5-fluoro-phenyl)-4′-[5-chloro-2-(2-methanesulfonylamino-1,1-dimethyl-2-oxo-ethoxy)-phenyl]spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

chiral (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(2-methanesulfonylamino-1,1-dimethyl-ethoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(1-methoxylcarbamoyl-1-methyl-ethoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(1-cyanocarbamoyl-1-methyl-ethoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(1-hydroxycarbamoyl-1-methyl-ethoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-fluoro-2-(2-methanesulfonylamino-1,1-dimethyl-2-oxo-ethoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(4-methoxy-phenoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(2-tert-butoxycarbonylamino-ethoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

chiral (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(2-tert-butoxycarbonylamino-ethoxy)-phenyl]-2′-(5-fluoro-2-methyl phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione and

racemic (2′S,3S,4′R)-6-chloro-4′-{5-chloro-2-[(2-cyclobutanecarbonyl-amino)-ethoxy]-phenyl}-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione.

9. A compound of claim 1 selected from the group consisting of

chiral (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(2-cyano-2-cyclopropyl-methoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(1-cyano-cyclopentyl-methoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-cyanomethoxy-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

chiral (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-cyanomethoxy-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-4′-[2-(4-tert-butoxycarbonyl-piperazin-1-yl)-5-chloro-phenyl]-6-chloro-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(piperazin-1-yl)-phenyl]-2′-(5-fluoro-2-methyl phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-4′-[2-(4-acetyl-piperazin-1-yl)-5-chloro-phenyl]-6-chloro-2′-(5-fluoro-2-methyl phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-{5-chloro-2-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-phenyl}-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

chiral (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(2-cyclopropanesulfonylamino-1,1-dimethyl-2-oxo-ethoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

chiral (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(2-trifluoro-methanesulfonylamino-1,1-dimethyl-2-oxo-ethoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′R,3S,4′R)-4′-[5-chloro-2-(2-methanesulfonylamino-1,1-dimethyl-2-oxo-ethoxy)-phenyl]-6-chloro-2′-(2,3-difluoro-6-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione and

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(2-methanesulfonylamino-2-oxo-ethoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione.

10. A compound of claim 1 selected from the group consisting of

racemic (2′S,3S,4′R)-4′-[5-chloro-2-(2-methanesulfonylamino-1,1-dimethyl-2-oxo-ethoxy)-phenyl]-6-chloro-2′-(5-chloro-2-methoxy-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(1-ethyl-1-hydroxycarbonyl-propoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(1-ethyl-1-methanesulfonylaminocarbonyl-propoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

chiral (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(1-ethyl-1-methanesulfonylaminocarbonyl-propoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(1-ethyl-1-dimethylcarbamoyl-propoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

chiral (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(1-ethyl-1-dimethylcarbamoyl-propoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-{5-chloro-2-[1-ethyl-1-(2-hydroxy-ethylcarbamoyl)-propoxy]-phenyl}-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4R)-6-chloro-4′-{5-chloro-2-[1-ethyl-1-((S)-2,3-dihydroxy-propylcarbamoyl)-propoxy]-phenyl}-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

chiral (2′S,3S,4′R)-6-chloro-4′-{5-chloro-2-[1-ethyl-1-((S)-2,3-dihydroxy-propylcarbamoyl)-propoxy]-phenyl}-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-{5-chloro-2-[1-ethyl-1-(pyrrolidine-1-carbonyl)-propoxy]-phenyl}-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

chiral (2′S,3S,4′R)-6-chloro-4′-{5-chloro-2-[1-ethyl-1-(pyrrolidine-1-carbonyl)-propoxy]-phenyl}-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione and

racemic (2′S,3S,4′R)-6-chloro-4′-{5-chloro-2-[1-ethyl-1-((S)-3-hydroxy-pyrrolidine-1-carbonyl)-propoxy]-phenyl}-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione.

11. A compound of claim 1 selected from the group consisting of

chiral (2′S,3S,4′R)-6-chloro-4′-{5-chloro-2-[1-ethyl-1-((S)-3-hydroxy-pyrrolidine-1-carbonyl)-propoxy]-phenyl}-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-{5-chloro-2-[1-ethyl-1-((R)-3-hydroxy-pyrrolidine-1-carbonyl)-propoxy]-phenyl}-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

chiral (2′S,3S,4′R)-6-chloro-4′-{5-chloro-2-[1-ethyl-1-((R)-3-hydroxy-pyrrolidine-1-carbonyl)-propoxy]-phenyl}-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(1-carbamoyl-1-ethyl-propoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

chiral (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(1-carbamoyl-1-ethyl-propoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(1-ethyl-1-methanesulfonylaminocarbonyl-propoxy)-phenyl]-2′-(5-chloro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

chiral (2′S,3S,4′R)-1-acetyl-6-chloro-4′-[5-chloro-2-(1-ethyl-1-methanesulfonylaminocarbonyl-propoxy)-phenyl]-2′-(5-chloro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

chiral (2′R,3R,4′S)-6-chloro-4′-[5-chloro-2-(1-ethyl-1-methanesulfonylaminocarbonyl-propoxy)-phenyl]-2′-(5-chloro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

chiral (2′S,3S,4′R)-4′-[5-chloro-2-(2-ethanesulfonylamino-1,1-dimethyl-2-oxo-ethoxy)-phenyl]-6-chloro-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-4′-[5-chloro-2-(2-methanesulfonylamino-1,1-dimethyl-2-oxo-ethoxy)-phenyl]-6-chloro-2′-(5-methyl-2-methoxy-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(3-methanesulfonylamino-2,2-dimethyl-3-oxo-propoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione and

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(2-methanesulfonylamino-1,1-dimethyl-2-oxo-ethoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione.

12. A compound of claim 1 selected from the group consisting of

chiral (2′R,3R,4′S)-6-chloro-4′-[5-chloro-2-(2-methanesulfonylamino-1,1-dimethyl-2-oxo-ethoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(2-methanesulfonylamino-1,1-dimethyl-2-oxo-ethoxy)-phenyl]-2′-(5-chloro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

chiral (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(2-methanesulfonylamino-1,1-dimethyl-2-oxo-ethoxy)-phenyl]-2′-(5-chloro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

chiral (2′S,3S,4′R)-6-chloro-4′-{5-chloro-2-[2-(2-methoxy-ethanesulfonylamino)-1,1-dimethyl-2-oxo-ethoxy]-phenyl}-2′-(5-fluoro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

chiral (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(1-methanesulfonylaminocarbonyl-1-propyl-butoxy)-phenyl]-2′-(5-chloro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(1-methanesulfonylaminocarbonyl-1-propyl-butoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

chiral (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(1-methanesulfonylaminocarbonyl-1-propyl-butoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-bromo-4′-[5-chloro-2-(1-ethyl-1-methanesulfonylaminocarbonyl-propoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-6-chloro-4′-(5-chloro-2-methanesulfinylmethoxy-phenyl)-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione,

racemic (2′S,3S,4′R)-[2-(tert-butylsulfamoyl-methoxy)-5-chloro-phenyl]-6-chloro-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione and

racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(2-methanesulfonylamino-1,1-diethyl-2-oxo-ethoxy)-phenyl]-5-fluoro-2′-(5-fluoro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione.