Granted Patent
B2
US 7,786,071 · App. 10/547,771 · Granted Aug 31, 2010
Pon polypeptides polynucleotides encoding same and compositions and methods utilizing same
Assignee:
Yeda Research And Development Co. Ltd.
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Abstract
Isolated polynucleotides and polypeptides encoded therefrom are provided. These include mutated PON enzymes with increased, modified or substantially the same substrate specificity as compared to respective wild-type PON. Also provided are kits and methods using these enzymes.
Claims (2)
1. An isolated polypeptide comprising the amino acid sequence of SEQ ID NO: 56.
2. A pharmaceutical composition comprising the isolated polypeptide of claim 1 and a pharmaceutically accepted carrier.
Assignments (3)
CONFIRMATORY LICENSE
Recorded Nov 18, 2010
From: WEIZMANN INSTITUTE OF SCIENCE
To: US ARMY, SECRETARY OF THE ARMY
Reel/Frame 025387/0587 →
CONFIRMATORY LICENSE
Recorded Sep 25, 2006
From: WEIZMANN INSTITUTE OF SCIENCE
To: US GOVERNMENT - SECRETARY FOR THE ARMY
Reel/Frame 018294/0583 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 29, 2005
From: TAWFIK, DAN S.; AHARONI, AMIR; GAYDUKOV, LEONID; SUSSMAN, JOEL L.; SILMAN, ISRAEL
To: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Reel/Frame 017272/0957 →
Continuity (3)
Provisional Application
6045126700
· Mar 4, 2003
Provisional Application
6051292500
· Oct 22, 2003