Compounds of the N-acylamino amide family compositions comprising them and uses thereof
The invention concerns novel compounds of the N-acylamino-amide family, compositions, in particular cosmetic or pharmaceutical, containing them, and their use for treating body or face skin ageing, whether chronobiologic or light-induced, and in particular skin ageing caused by decrease of skin elasticity and/or by collagen degradation in the structure for tissues.
1. A compound chosen from compounds of formula (I):
wherein:
Y is O,
R 1 is H, methyl, ethyl, propyl, or isopropyl,
R 2 is a linear, or branched C 1-18 alkyl,
R 3 is a radical chosen from those of formulae (II) and (III):
(II) -A-C 6 H (5-y) —B y wherein y is 0 and A is —CH 2 , —CH 2 CH 2 , or —CH 2 CH 2 CH 2 , and
(III) —C 6 H (5-y′) —B y′ wherein y′ is 0 or 1, and B is a perfluorinated hydrocarbon-based radical chosen from a methyl, theyl, propyl or isopropyl radical,
X is —OH or —OR 4 wherein R 4 is a linear, branched, or cyclic C 1-6 alkyl,
the mineral acid and organic acid salts thereof, and the optical isomers thereof, in isolated form and as a racemic mixture.
2. The compound according to claim 1 , wherein B is —CF 3 .
3. The compound according to claim 1 , wherein R 1 is methyl.
4. The compound according to claim 1 , wherein R 2 is methyl, ethyl, propyl, isopropyl, n-butyl, tert-butyl or isobutyl.
5. The compound according to claim 4 , wherein R 2 is isopropyl.
6. The compound according to claim 1 , wherein X is —OH, —OCH 3 , —OC 2 H 5 , —OC 3 H 7 , or —OC 4 H 9 .
7. The compound according to claim 1 , wherein the compound is chosen from:
{2-[acetyl(3-trifluoromethylphenyl)amino]-3-methylbutyrylamino}acetic acid,
ethyl {2-[acetyl(3-trifluoromethylphenyl)amino]-3-methylbutyrylamino}acetate,
[2-(acetylbenzylamino)-3-methylbutyrylamino]acetic acid, and
ethyl[2-(acetylbenzylamino)-3-methylbutyrylamino]acetate.