Therapeutic compounds
Compounds of formula (I) below are disclosed. Their use as medicaments is described, in particular for the treatment of pain or inflammation: wherein: when X=Y=Z=OH, R 1 is OCH 2 CF 2 CF 3 , phenoxy (substituted with 3-(4-trifluoromethylphenyl), 3,4-dichloro, (3-trifluoromethyl,4-fluoro), (3-trifluoromethyl,4-chloro), (3-chloro, 4-cyano), or 3,5-bis(trifluoromethyl)), 1-piperazinyl(4-(3,4-dichlorophenyl)), phenyl (substituted with 3,4-dichloro, 3,5-difluoro, 3,5-bis(trifluoromethyl) or 3,4,5-trifluoro) or 2-benzofuranyl; or when X=Y=OH and Z=OMe, R 1 is OCH 3 , OCH 2 CHF 2 , OCH 2 cyclopentyl, O-(2,5-difluorophenyl) or (S)-sec-butylamino; or when X=H and Y=Z=OH, R 1 is n-hexylamino or cyclopentylamino; or when (IV) X=Z=OH and Y=H, R 1 is cyclopentylamino; or a pharmaceutically acceptable salt thereof.
1. A compound of the following general formula:
wherein:
when X=Y=Z=OH, R1 is OCH2CF2CF3, phenoxy (substituted with 3-(4-trifluoromethylphenyl), 3,4-dichloro, (3-trifluoromethyl,4-fluoro), (3-trifluoromethyl,4-chloro), (3-chloro, 4-cyano), or 3,5-bis(trifluoromethyl)), 1-piperazinyl(4-(3,4-dichlorophenyl)), phenyl (substituted with 3,4-dichloro, 3,5-difluoro, 3,5-bis(trifluoromethyl) or 3,4,5-trifluoro) or 2-benzofuranyl; or
when X=H and Y=Z=OH, R1 is n-hexylamino or cyclopentylamino; or
when X=Z=OH and Y=H, R1 is cyclopentylamino;
or a pharmaceutically acceptable salt thereof.
2. A compound according to claim 1 , wherein each of X, Y and Z is OH.
3. A pharmaceutical composition comprising a compound according to claim 1 , and a physiologically acceptable carrier, excipient, or diluent.
4. The pharmaceutical composition according to claim 3 , further comprising an NSAID or a DMARD.
5. The pharmaceutical composition according to claim 3 , further comprising an anti-pathogenic agent.