Pyrimidine sulphonamide derivatives as chemokine receptor modulators
A compound of formula (1), or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof and pharmaceutical compositions comprising these, all for use in the treatment of chemokine mediated diseases and disorders.
1. A compound of the formula:
or a pharmaceutically acceptable salt thereof.
2. A compound as claimed in claim 1 , which is N-[2-[[(2,3-Difluorophenyl)methyl]thio]-6-{[(1R,2S)-2,3-dihydroxy-1-methylpropyl]oxy}-4-pyrimidinyl]-1-azetidinesulfonamide or a pharmaceutically acceptable salt thereof.
3. A compound as claimed in claim 1 , which is N-[2-[[(2,3-Difluorophenyl)methyl]thio]-6-{[(1R,2S)-2,3-dihydroxy-1-methylpropyl]oxy}-4-pyrimidinyl]-1-azetidinesulfonamide.
4. A pharmaceutical composition comprising a compound or a pharmaceutically acceptable salt thereof, as claimed in claim 1 , and a pharmaceutically-acceptable diluent or carrier.
5. A pharmaceutical composition comprising a compound or a pharmaceutically acceptable salt thereof, as claimed in claim 2 , and a pharmaceutically-acceptable diluent or carrier.
6. A pharmaceutical composition comprising a compound as claimed in claim 3 and a pharmaceutically-acceptable diluent or carrier.