Therapeutic compounds and methods of use
Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
1. A compound having the formula:
wherein R 1 is a cyano group, R 2 is methyl, and R 3 is alkoxy.
2. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
3. The pharmaceutical composition of claim 2 , wherein the composition is formulated as a hard or soft capsule, a tablet, a syrup, a suspension, a wafer, or an elixir.
4. The pharmaceutical composition of claim 3 , wherein the soft capsule of the composition is a gelatin capsule.
5. The pharmaceutical composition of claim 2 , wherein the composition further comprises a protective coating.
6. The pharmaceutical composition of claim 2 , wherein the composition further comprises an agent that delays absorption.
7. The pharmaceutical composition of claim 2 , wherein the composition further comprises an agent that enhances solubility or dispersibility.
8. A pharmaceutical composition comprising a compound of claim 1 and a liposome, wherein the compound is dispersed in the liposome.
9. A pharmaceutical composition comprising a compound of claim 1 , oil and water, wherein the compound is dispersed in an oil and water emulsion or a water and oil emulsion.
10. A compound having the following formula:
11. A method of treating a disorder, wherein the disorder is breast cancer, prostate cancer, colon cancer, brain cancer, melanoma, pancreatic cancer, ovarian cancer, leukemia, or bone cancer comprising administering to said subject a therapeutically effective dosage of a compound having the formula:
wherein R 1 is a cyano group, R 2 is methyl, and R 3 is alkoxy,
such that the disorder is treated.
12. The method of claim 11 , wherein the disorder is breast cancer, prostate cancer, colon cancer, brain cancer, melanoma, pancreatic cancer, ovarian cancer, leukemia, or bone cancer.
13. The method of claim 11 , wherein said subject is a mammal.
14. The method of claim 13 , wherein said mammal is a human.
15. A compound of the formula: