Pharmaceutical formulations of endo-N-(9-methyl-9-azabicyclo[3,3.1]non-3-yl)-1-methyl-1H-indazole-3-carboxamide hydrochloride
View Patent ↗A pharmaceutical formulation suitable for multi-dose administration comprising endo-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1-methyl-1H-indazole-3-carboxanide hydrochloride, a preservative selected from the group consisting of alkyl paraben and phenol, and a buffer selected from the group consisting of acetate and phosphate buffers is disclosed.
1. A pharmaceutical formulation comprising endo-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1-methyl-1H-indazole-3-carboxamide hydrochloride, a preservative of alkyl paraben, and an acetate buffer.
2. A formulation according to claim 1 wherein the preservative comprises one or more of a C 1-4 alkyl paraben and salts thereof.
3. A formulation according to claim 2 wherein the preservative comprises methylparaben and propylparaben.
4. A pharmaceutical formulation comprising endo-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1-methyl-1H-indazole-3-carboxamide hydrochloride, a combination of methyl- and propylparaben as preservative, and an acetate buffer.
5. A pharmaceutical formulation comprising endo-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1-methyl-1H-indazole-3-carboxamide hydrochloride, a preservative of phenol, and a buffer selected from the group consisting of acetate and phosphate buffers.
6. The formulation according to claim 5 wherein the formulation is a sterilized formulation.