Suppression of high rate pacing for reducing myocardial ischemic irritability

1. A method of controlling delivery of therapy in a medical device, comprising:

sensing physiologic signals of a patient;

delivering the therapy in response to the sensed signals;

determining the presence of increased myocardial irritability that occurs in response to the delivered therapy; and

adjusting an upper pacing rate limit associated with the delivering of the therapy to an adjusted upper pacing rate limit below a programmed upper pacing rate limit in response to determining the presence of increased myocardial irritability occurring in response to the delivered therapy, wherein determining the presence of increased myocardial irritability comprises detecting one of a non-sustained ventricular tachycardia event that spontaneously reverts to normal sinus rhythm, a non-sustained ventricular fibrillation event that spontaneously reverts to normal sinus rhythm, a minimum rate of premature ventricular contractions, and prediction of a ventricular tachycardia cluster.

2. The method of claim 1 , further comprising:

determining whether a current pacing rate is greater than the adjusted upper pacing rate limit; and

delivering the therapy at the adjusted upper pacing rate limit in response to the current pacing rate being greater than the adjusted upper pacing rate limit.

3. The method of claim 1 , further comprising:

determining whether a predetermined time period associated with the adjusted upper pacing rate limit has expired; and

adjusting the upper pacing rate limit from the adjusted upper pacing rate limit to the programmed upper pacing rate limit in response to determining that the predetermined time period has expired.

4. The method of claim 3 , further comprising:

monitoring physiologic data of the patient; and

adjusting the predetermined time period in response to the monitored physiologic data.

5. The method of claim 1 , further comprising monitoring physiologic data of the patient, wherein the adjusted upper pacing rate limit corresponds to the monitored physiologic data.

6. The method of claim 1 , further comprising:

determining whether a predetermined time period associated with the adjusted upper pacing rate limit has expired;

determining the presence of increased myocardial irritability that occurs in response to the delivering of the therapy at the adjusted upper pacing rate limit; and

adjusting the upper pacing rate limit from the adjusted upper pacing rate limit to the programmed upper pacing rate limit in response to determining that the predetermined time period has expired and determining no increased myocardial irritability being present in response to the delivering of the therapy at the adjusted upper pacing rate limit.

7. The method of claim 1 , further comprising;

determining whether a predetermined time period associated with the adjusted upper pacing rate limit has expired;

determining, in response to determining that the predetermined time period has expired, the presence of increased myocardial irritability that occurs in response to the delivering of the therapy at the adjusted upper pacing rate limit;

adjusting the upper pacing rate limit from the adjusted upper pacing rate limit to the programmed upper pacing rate limit in response to determining no increased myocardial irritability being present in response to the delivering of the therapy at the adjusted upper pacing rate limit; and

adjusting the predetermined time period in response to determining increased myocardial irritability is present in response to the delivering of the therapy at the adjusted upper pacing rate limit.

8. The method of claim 7 , further comprising monitoring physiologic data of the patient, wherein the predetermined time period is adjusted in response to the monitored physiologic data.

9. The method of claim 1 , wherein adjusting the upper pacing rate limit comprises:

determining whether the therapy is one of a short term therapy having a first duration or a long term therapy having a second duration greater than the first duration; and

adjusting the upper pacing rate limit in response to determining the presence of increased myocardial irritability occurring in response to the delivered therapy and determining that the therapy is a long term therapy.

10. A medical device for delivering therapy to a patient, comprising:

a plurality of electrodes configured to sense physiologic signals of a patient and deliver the therapy;

a control unit, coupled to the plurality of electrodes, configured to control delivery of the therapy in response to the sensed signals;

a microprocessor, coupled to the control unit, configured to determine the presence of increased myocardial irritability that occurs in response to the delivered therapy,

wherein the control unit is further configured to adjust an upper pacing rate limit associated with the delivery of the therapy to an adjusted upper pacing rate limit below a programmed upper pacing rate limit in response to the microprocessor determining the presence of increased myocardial irritability that occurs in response to the delivered therapy, wherein determining the presence of increased myocardial irritability comprises detecting one of a non-sustained ventricular tachycardia event that spontaneously reverts to normal sinus rhythm, a non-sustained ventricular fibrillation event that spontaneously reverts to normal sinus rhythm, a minimum rate of premature ventricular contractions, and prediction of a ventricular tachycardia cluster.

11. The device of claim 10 , wherein the control unit is configured to control the delivery of the therapy at the adjusted upper pacing rate limit in response to a current pacing rate being greater than the adjusted upper pacing rate limit.

12. The device of claim 10 , wherein the microprocessor determines whether a predetermined time period associated with the adjusted upper pacing rate limit has expired, and the control unit adjusts the upper pacing rate limit from the adjusted upper pacing rate limit to the programmed upper pacing rate limit in response to determining that the predetermined time period has expired.

13. The device of claim 12 , wherein the microprocessor monitors physiologic data of the patient, and the control unit adjusts the predetermined time period in response to the monitored physiologic data.

14. The device of claim 10 , wherein the microprocessor monitors physiologic data of the patient, wherein the adjusted upper pacing rate limit corresponds to the monitored physiologic data.

15. The device of claim 10 , wherein the microprocessor determines whether a predetermined time period associated with the adjusted upper pacing rate limit has expired and determines the presence of increased myocardial irritability that occurs in response to the delivery of the therapy at the adjusted upper pacing rate limit, and wherein the control unit adjusts the upper pacing rate limit from the adjusted upper pacing rate limit to the programmed upper pacing rate limit in response to the predetermined time period having expired and no increased myocardial irritability being present in response to the delivering of the therapy at the adjusted upper pacing rate limit.

16. The device of claim 10 , wherein the microprocessor determines whether a predetermined time period associated with the adjusted upper pacing rate limit has expired and determines, in response to determining that the predetermined time period has expired, the presence of increased myocardial irritability that occurs in response to the delivery of the therapy at the adjusted upper pacing rate limit, and wherein the control unit adjusts the upper pacing rate limit from the adjusted upper pacing rate limit to the programmed upper pacing rate limit in response to no increased myocardial irritability being present in response to the delivering of the therapy at the adjusted upper pacing rate limit, and adjusts the predetermined time period in response to increased myocardial irritability occurring in response to the delivery of the therapy at the adjusted upper pacing rate limit.

17. The device of claim 16 , wherein the microprocessor monitors physiologic data of the patient, and wherein the predetermined time period is adjusted in response to the monitored physiologic data.

18. The medical device of claim 10 , wherein the microprocessor determines whether the delivered therapy is one of a short term therapy having a first duration and or a long term therapy having a second duration greater than the first duration, and wherein the control unit adjusts the upper pacing rate limit in response to the microprocessor determining the presence of increased myocardial irritability that occurs in response to the delivered therapy and determining that the therapy is a long term therapy.

19. A method of controlling delivery of therapy in a medical device, comprising:

sensing physiologic signals of a patient;

determining the presence of a cardiac event in response to the sensed signals;

delivering the therapy at a predetermined pacing rate in response to the determined cardiac event;

determining whether the delivered therapy is one of a short term therapy having a first duration and a long term therapy having a second duration greater than the first duration;

continuing delivery of the therapy at the predetermined pacing rate in response to the delivered therapy being a short term therapy;

determining, in response to the delivered therapy being a long term therapy, whether an increase in myocardial irritability occurs in response to the delivered therapy; and

reducing an upper pacing rate limit associated with the delivering of the therapy to an adjusted upper pacing rate limit below a programmed upper rate limit in response to an increase myocardial irritability occurring in response to the delivered therapy, wherein determining whether an increase in myocardial irritability occurs comprises detecting one of a non-sustained ventricular tachycardia event that spontaneously reverts to normal sinus rhythm, a non-sustained ventricular fibrillation event that spontaneously reverts to normal sinus rhythm, a minimum rate of premature ventricular contractions, and prediction of a ventricular tachycardia cluster.

20. The method of claim 19 , further comprising:

determining, during delivery of the therapy utilizing the adjusted upper pacing rate limit, an indicated pacing rate, the indicated pacing rate corresponding to one of a sensor-indicated pacing rate and an intrinsic pacing rate;

determining whether the indicated pacing rate is greater than the adjusted upper pacing rate limit;

delivering the therapy at the indicated pacing rate in response to the indicated pacing rate not being greater than the adjusted upper pacing rate limit; and

delivering the therapy at the adjusted upper pacing rate limit in response to the indicated pacing rate being greater than the adjusted upper pacing rate limit.