Compounds, compositions and methods

1. At least one chemical entity chosen from compounds of Formula I

and pharmaceutically acceptable salts, wherein

T is —O—;

W, X, Y, and Z are —C═;

R 1 is optionally substituted alkyl;

R 2 is optionally substituted pyridin-3-yl;

R 3 is hydrogen;

R 4 is fluoro; and

R 5 is hydrogen;

R 6 and R 7 are hydrogen; and

R 13 is hydrogen.

2. At least one chemical entity of claim 1 wherein R 1 is substituted lower alkyl optionally substituted with one or two groups chosen from optionally substituted alkoxy and optionally substituted amino.

3. At least one chemical entity of claim 1 where R 1 is selected from 1-methoxypropan-2-yl, (1-acetamidocyclopentyl)methyl, 2-acetamido-2-methylprop-1-yl, 2-(methoxycarbonylamino)eth-1-yl, 2-(tert-butoxycarbonyl(methyl)amino)eth-1-yl, 1-(methoxycarbonyl(methyl)amino)propan-2-yl, 1-(tert-butoxycarbonyl(methyl)amino)propan-2-yl, 2-acetamidoeth-1-yl, 2-(N-methylacetamido)eth-1-yl, 1-(N-methylacetamido)propan-2-yl, 2-(N,N-dimethylsulfamoylamino)eth-1-yl, 2-((N,N-dimethylsulfamoyl)(methyl)amino)eth-1-yl, 1-((N,N-dimethylsulfamoyl)(methyl)amino)propan-2-yl, 2-(ethylsulfonamido)eth-1-yl, 2-(N-methylethylsulfonamido)eth-1-yl, 1-(N-methylethylsulfonamido)propan-2-yl, 1-(N-methylpropan-2-ylsulfonamido)propan-2-yl, 2-(N-methylpropan-2-ylsulfonamido)eth-1-yl, 2-(2-cyano-1,3,3-trimethylguanidino)eth-1-yl, 2-(methylamino)eth-1-yl, 5-methyl-1,1-dioxo-1λ 6 -[1,2,5]thiadiazolidin-2-yl-ethyl; 5-methyl-1,1-dioxo-1λ 6 -[1,2,5]thiadiazolidin-3-yl-methyl; 2,6-dimethyl-1,1-dioxo-1λ 6 -[1,2,6]thiadiazinan-4-yl-methyl,

4. At least one chemical entity of claim 3 where R 1 is selected from 2-(methoxycarbonylamino)eth-1-yl, 1-(methoxycarbonyl(methyl)amino)propan-2-yl, 2-acetamido-2-methylprop-1-yl, 2-(N,N-dimethylsulfamoylamino)eth-1-yl, 2-((N,N-dimethylsulfamoyl)(methyl)amino)eth-1-yl, 1-((N,N-dimethylsulfamoyl)(methyl)amino)propan-2-yl, 2-(ethylsulfonamido)eth-1-yl, 2-(N-methylethylsulfonamido)eth-1-yl, 1-(N-methylethylsulfonamido)propan-2-yl, 1-(N-methylpropan-2-ylsulfonamido)propan-2-yl, and 2-(N-methylpropan-2-ylsulfonamido)eth-1-yl.

5. At least one chemical entity of claim 1 wherein R 2 is pyridin-3-yl optionally substituted with lower alkyl.

6. At least one chemical entity of claim 1 wherein the compound of Formula I is chosen from

N-[5-fluoro-3-(2-methoxy-isopropoxy)phenyl][(6-methoxy(3-pyridyl))amino]carboxamide;

N-[5-fluoro-3-(2-methoxy-isopropoxy)phenyl](3-pyridylamino)carboxamide;

[(6-methoxy(3-pyridyl))amino]-N-[3-(methylethoxy)phenyl]carboxamide;

N-[({5-fluoro-3-[(N-(3-pyridyl)carbamoyl)amino]phenoxy}methyl)cyclopentyl]acetamide;

N-(2-{5-fluoro-3-[(N-(3-pyridyl)carbamoyl)amino]phenoxy}-tert-butyl)acetamide;

N-{2-[5-fluoro-3-({N-[6-(trifluoromethyl)(3-pyridyl)]carbamoyl}amino)phenoxy]-tert-butyl}acetamide;

N-[2-(5-fluoro-3-{[N-(6-methoxy(3-pyridyl))carbamoyl]amino}phenoxy)-tert-butyl]acetamide;

N-({[3-fluoro-5-({[6-(trifluoromethyl)(3-pyridyl)]amino}carbonylamino)phenoxy]methyl}cyclopentyl)acetamide;

N-{[(3-fluoro-5-{[(6-methoxy(3-pyridyl))amino]carbonylamino}phenoxy)methyl]cyclopentyl}acetamide;

N-{5-fluoro-3-[2-(methoxycarbonylamino)ethoxy]phenyl}(3-pyridylamino)carboxamide;

N-(2-{3-fluoro-5-[(3-pyridylamino)carbonylamino]phenoxy}ethyl)acetamide;

N-[3-(2-{[(dimethylamino)sulfonyl]amino}ethoxy)-5-fluorophenyl](3-pyridylamino)carboxamide;

N-(3-{2-[(ethylsulfonyl)amino]ethoxy}-5-fluorophenyl)(3-pyridylamino)carboxamide;

N-(2-{3-fluoro-5-[(3-pyridylamino)carbonylamino]phenoxy}ethyl)methoxy-N-methylcarboxamide;

N-(2-{3-fluoro-5-[(3-pyridylamino)carbonylamino]phenoxy}ethyl)-N-methylacetamide;

N-[3-(2-{[(dimethylamino)sulfonyl]methylamino}ethoxy)-5-fluorophenyl](3-pyridylamino)carboxamide;

N-(3-{2-[(ethylsulfonyl)methylamino]ethoxy}-5-fluorophenyl)(3-pyridylamino)carboxamide;

N-[3-(2-{[(1Z)-1-(dimethylamino)-2-cyano-2-azavinyl]methylamino}ethoxy)-5-fluorophenyl](3-pyridylamino)carboxamide;

N-[3-((1R)-2-{[dimethylamino)sulfonyl]methylamino}-isopropoxy)-5-fluorophenyl](3-pyridylamino)carboxamide;

N-(3-{(1R)-2-[(ethylsulfonyl)methylamino]-isopropoxy}-5-fluorophenyl)(3-pyridylamino)carboxamide;

N-(3-{(1R)-2-[(tert-butoxy)-N-methylcarbonylamino]-isopropoxy}-5-fluorophenyl)(3-pyridylamino)carboxamide;

N-{3-[(1R)-2-(methoxy-N-methylcarbonylamino)-isopropoxy]-5-fluorophenyl}(3-pyridylamino)carboxamide;

N-{3-[(1R)-1-methyl-2-(methylamino)ethoxy]-5-fluorophenyl}(3-pyridylamino)carboxamide;

N-[3-((1S)-2-{[dimethylamino)sulfonyl]methylamino}-isopropoxy)-5-fluorophenyl]-3-pyridylamino)carboxamide;

N-(3-{(1S)-2-[(ethylsulfonyl)methylamino]-isopropoxy}-5-fluorophenyl)(3-pyridylamino)carboxamide;

N-((2S)-2-{3-fluoro-5-[(3-pyridylamino)carbonylamino]phenoxy}propyl)methoxy-N-methylcarboxamide;

N-((2S)-2-{3-fluoro-5-[(3-pyridylamino)carbonylamino]phenoxy}propyl)-N-methylacetamide;

N-[3-(2-{[(1E)-1-(dimethylamino)-2-cyano-2-azavinyl]methylamino}(1S)-isopropoxy)-5-fluorophenyl](3-pyridylamino)carboxamide;

N-[3-((1S)-1-methyl-2-{methyl[(methylethyl)sulfonyl]amino}ethoxy)-5-fluorophenyl](3-pyridylamino)carboxamide;

N-((2R)-2-{3-fluoro-5-[(3-pyridylamino)carbonylamino]phenoxy}propyl)-N-methylacetamide;

N-[3-(2-{[(1E)-1-(dimethylamino)-2-cyano-2-azavinyl]methylamino}(1R)-isopropoxy)-5-fluorophenyl](3-pyridylamino)carboxamide;

N-[3-(2-{[(dimethylamino)sulfonyl]methylamino}ethoxy)-5-fluorophenyl][(6-methyl(3-pyridyl))amino]carboxamide;

N-(3-{2-[(ethylsulfonyl)methylamino]ethoxy}-5-fluorophenyl)[(6-methyl(3-pyridyl))amino]carboxamide;

N-[5-fluoro-3-(2-{methyl[(methylethyl)sulfonyl]amino}ethoxy)phenyl][(6-methyl(3-pyridyl))amino]carboxamide;

N-[3-(2-{[(dimethylamino)sulfonyl]methylamino}ethoxy)-5-fluorophenyl][(4-fluorophenyl)amino]carboxamide;

N-(3-{2-[(ethylsulfonyl)methylamino]ethoxy}-5-fluorophenyl)[(4-fluorophenyl)amino]carboxamide;

N-[5-fluoro-3-(2-{methyl[(methylethyl)sulfonyl]amino}ethoxy)phenyl][(4-fluorophenyl)amino]carboxamide;

N-(3-{(1R)-2-[(tert-butoxy)-N-methylcarbonylamino]-isopropoxy}-5-fluorophenyl)[(6-methyl(3-pyridyl))amino]carboxamide;

N-[3-((1R)-2-{[(dimethylamino)sulfonyl]methylamino}-isopropoxy)-5-fluorophenyl][(6-methyl(3-pyridyl))amino]carboxamide;

N-(3-{(1R)-2-[(ethylsulfonyl)methylamino]-isopropoxy}-5-fluorophenyl)[(6-methyl(3-pyridyl))amino]carboxamide;

N-[3-((1R)-1-methyl-2-{methyl[(methylethyl)sulfonyl]amino}ethoxy)-5-fluorophenyl][(6-methyl(3-pyridyl))amino]carboxamide;

N-{3-[(1R)-2-(methoxy-N-methylcarbonylamino)-isopropoxy]-5-fluorophenyl}[(6-methyl(3-pyridyl))amino]carboxamide;

N-[3-((1S)-2-{[(dimethylamino)sulfonyl]methylamino}-isopropoxy)-5-fluorophenyl][(6-methyl(3-pyridyl))amino]carboxamide;

N-(3-{(1S)-2-[(ethylsulfonyl)methylamino]-isopropoxy}-5-fluorophenyl)[(6-methyl(3-pyridyl))amino]carboxamide;

N-[3-((1S)-1-methyl-2-{methyl[(methylethyl)sulfonyl]amino}ethoxy)-5-fluorophenyl][(6-methyl(3-pyridyl))amino]carboxamide;

N-[(2S)-2-(3-fluoro-5-{[(6-methyl(3-pyridyl))amino]carbonylamino}phenoxy)propyl]methoxy-N-methylcarboxamide;

N-[(2S)-2-(3-fluoro-5-{[(6-methyl(3-pyridyl))amino]carbonylamino}phenoxy)propyl]-N-methylacetamide;

N-[3-(2-{[(1E)-1-(dimethylamino)-2-cyano-2-azavinyl]methylamino}(1S)-isopropoxy)-5-fluorophenyl][(6-methyl(3-pyridyl))amino]carboxamide;

N-{3-[2-{[(dimethylamino)sulfonyl]methylamino}-1-({[(dimethylamino)sulfonyl]methylamino}methyl)ethoxy]-5-fluorophenyl}(3-pyridylamino)carboxamide;

N-{3-[2-{[(dimethylamino)sulfonyl]methylamino}-1-({[(dimethylamino)sulfonyl]methylamino}methyl)ethoxy]-5-fluorophenyl}[(6-methyl(3-pyridyl))amino]carboxamide;

N-{5-fluoro-3-[2-(5-methyl-1,1-dioxo(1,2,5-thiadiazolidin-2-yl))ethoxy]phenyl}(3-pyridylamino)carboxamide;

N-{5-fluoro-3-[2-(5-methyl-1,1-dioxo(1,2,5-thiadiazolidin-2-yl))ethoxy]phenyl}[(6-methyl(3-pyridyl))amino]carboxamide;

N-{3-[(2,5-dimethyl-1,1-dioxo(1,2,5-thiadiazolidin-3-yl))methoxy]-5-fluorophenyl}(3-pyridylamino)carboxamide; and

N-{3-[(2,5-dimethyl-1,1-dioxo(1,2,5-thiadiazolidin-3-yl))methoxy]-5-fluorophenyl}[(6-methyl(3-pyridyl))amino]carboxamide.

7. A pharmaceutical composition comprising a pharmaceutically acceptable excipient or adjuvant and at least one chemical entity of claim 1 .

8. The pharmaceutical composition of claim 7 wherein the composition is formulated in a form chosen from injectable fluids, aerosols, tablets, pills, capsules, syrups, creams, gels, and transdermal patches.