Herbal extract for renal disorders
The present invention relates to the use of standardized extract of Tinospora cordifolia as an immunoadjuvant in the treatment of renal disorders such as nephrotic syndrome and chronic recurrent urinary tract infections, both complicated and uncomplicated. The present invention also relates to pharmaceutical compositions comprising the standardized extract of Tinospora cordifolia. The present invention further relates to a method of treatment of renal disorders such as recurrent urinary tract infection particularly occurring due to relapsing E. coli, Klebsiella and other gram negative infections and to a method of treatment of nephrotic syndrome using standardized extract of Tinospora cordifolia as an immunoadjuvant in conjunction with conventional therapy.
1. A method for the treatment of a chronic recurrent urinary tract infection in a mammal in need thereof, the method comprising administering to the mammal a composition of a standardized extract of Tinospora cordifolia as an immunoadjuvant in a dosage of 20 to 80 mg/kg body weight per day of the mammal, in conjunction with an antibacterial agent over a period ranging from 20 days to three months.
2. The method of claim 1 , wherein the chronic recurrent urinary tract infection is both complicated and uncomplicated.
3. The method of claim 1 , wherein the chronic recurrent urinary tract infection is caused due to relapsing bacterial infection.
4. The method of claim 3 , wherein the relapsing bacterial infection is E. coli or Klebsiella infection.
5. The method of claim 1 , wherein said composition comprising the standardized extract of Tinospora cordifolia is administered in a dosage of 20-25 mg/kg body weight over a period of one month.
6. The method of claim 1 , wherein said antibacterial agent is selected from the group consisting of ciprofloxacin, ofloxacin, norfloxacin, trimethoprim, sulfamethoxazole, amoxicillin, nitrofurantoin, ampicillin and lomefloxacin.