Non-invasive positioning system for locating the focus of high-intensity focused ultrasound
A non-invasive positioning system for determining the focus location of a HIFU device comprises a diagnostic ultrasound and the HIFU for ablating and removing tumor tissue. The imaging plane of the diagnostic ultrasound probe and the geometrical axis of a probe of the HIFU define an inclining angle during operation. When the imaging plane of the diagnostic ultrasound intersected to the focus of the HIFU transducer, a maximal convergent interference signals was obtained, so as to position the HIFU focus within tumors for precise ablation.
1. A positioning method for the focus location of a high-intensity focused ultrasound (HIFU) device in vivo, comprising steps of:
(i) scanning and estimating the location and size of a tumor in vivo using a diagnostic ultrasound device;
(ii) operating the HIFU device at a relatively low power to align the ultrasound provided thereby with the location of the tumor tissue detected in step (i);
(iii) adjusting the scanning angle of the diagnostic ultrasound device until maximal interference convergence is observed on the ultrasounds intersection provided respectively from the diagnostic ultrasound device and the HIFU device, wherein the inclining angle defined between geometric axes of the respective probes of the diagnostic ultrasound device and the HIFU device has a range from 85 to 160 degrees; and
(iv) determining the focus of the HIFU device by locating where the maximal interference convergence is observed using the diagnostic ultrasound device.
2. The positioning method for the focus location of the high-intensity focused ultrasound (HIFU) in vivo as claimed in claim 1 , wherein after step (iii), further comprises a step of: ablating the tumor tissue by operating HIFU at a relatively high power to remove the tumor tissue.
3. The positioning method for the focus location of the high-intensity focused ultrasound (HIFU) in vivo as claimed in claim 2 , wherein the relatively high power has a range from 30 W to 60 W (electrical power).
4. The positioning method for locating the focus of the high-intensity focused ultrasound (HIFU) in vivo as claimed in claim 1 , wherein the relatively low power of step (ii) is from 0.01 W to 5 W (electrical power).