Polymorphs of eltrombopag and eltrombopag salts and processes for preparation thereof
New polymorphs of Eltrombopag and Eltrombopag ethanolamine salt have been obtained and characterized. These polymorphs and pharmaceutical compositions comprising them are useful, for example, in treating conditions leading to thrombocytopenia.
1. Crystalline Eltrombopag Form I characterized by data selected from the group consisting of: a powder XRD pattern having peaks at 4.0, 7.3, 7.7, 12.1 and 16.1° 2θ±0.2° 2θ; a PXRD pattern as depicted in FIG. 1 ; a solid state 13 C NMR spectrum haying peaks at 166.9, 155.4, 134.1, 125.7 and 111.8 ±0.2 ppm; a solid state 13 C NMR spectrum as depicted in FIG. 35 ; and any combination thereof.
2. The crystalline Eltrombopag according to claim 1 , further characterized by data selected from the group consisting of: a powder XRD pattern having peaks at 8.8, 14.6, 17.6, 24.3 and 26.8° 2θ±0.2° 2θ; a DSC thermogram as depicted in FIG. 2 ; a solid state 13 C NMR spectrum having peaks at 141.4, 130.4, 119.8 and 117.8±0.2 ppm; and any combination thereof.
3. The crystalline Eltrombopag according to claim 1 , wherein the crystalline Eltrombopag is anhydrous.
4. Crystalline Eltrombopag Form I according to claim 1 , characterized by a powder XRD pattern having peaks at 4.0, 7.3, 7.7, 12.1 and 16.1° 2θ±0.2° 2θ.
5. Crystalline Eltrombopag form III characterized by data selected from the group consisting of: a powder XRD pattern having peaks at 9.2, 11.2, 12.2 and 14.0° 2θ±0.2° 2θ; a PXRD pattern as depicted in FIG. 3 ; a solid state 13 C NMR spectrum having peaks at 170.6, 128.7, 124.2 and 113.8±0.2 ppm; a solid state 13 C NMR spectrum as depicted in FIG. 36 ; and any combination thereof.
6. The crystalline Eltrombopag according to claim 5 , further characterized by data selected from the group consisting of: a powder XRD pattern having peaks at 5.3, 16.1, 22.4 and 24.3° 2θ±0.2° 2θ; a DSC thermogram as depicted in FIG. 4 ; a solid state 13 C NMR spectrum having peaks at 155.0, 141.0, 136.6 and 133.6±0.2 ppm; and any combination thereof.
7. Crystalline Eltrombopag form III according to claim 5 , characterized by a powder XRD pattern having peaks at 9.2, 11.2, 12.2 and 14.0° 2θ±0.2° 2θ.
8. Crystalline Eltrombopag Form V characterized by data selected from the group consisting of: a powder XRD pattern having peaks at 5.9, 8.2, 10.5 and 12.5° 2θ±0.2° 2θ; a PXRD pattern as depicted in FIG. 7 ; a solid state 13 C NMR spectrum having peaks at 142.0, 131.6, 114.9 and 67.8±0.2 ppm; a solid state 13 C NMR spectrum as depicted in FIG. 37 ; and any combination thereof.
9. The crystalline Eltrombopag according to claim 8 , further characterized by data selected from the group consisting of: a powder XRD pattern having peaks at 5.3, 9.2, 14.0, 23.5 and 25.0° 2θ±0.2° 2θ; a DSC thermogram as depicted in FIG. 8 ; a solid state 13 C NMR spectrum having peaks at 171.9, 155.4, 136.3 and 121.3 ±0.2 ppm; and any combination thereof.
10. Crystalline Eltrombopag Form V according to claim 8 , characterized by a powder XRD pattern having peaks at 5.9, 8.2, 10.5 and 12.5° 2θ±0.2° 2θ.
11. Crystalline Eltrombopag form XVI characterized by a data selected from a group consisting of: a powder XRD pattern having peaks at 7.1, 9.5, 13.9, 21.2 and 25.5° 2θ±0.2° 2θ; a PXRD pattern as depicted in FIG. 20 ; a solid state 13 C NMR spectrum having peaks at 168.7, 156.7, 127.6 and 112.8±0.2 ppm; a solid state 13 C NMR spectrum as depicted in FIG. 38 ; and any combination thereof.
12. The crystalline Eltrombopag according to claim 11 , characterized by data selected from the group consisting of: a powder XRD pattern having peaks at 5.9, 11.2, 15.4, 17.4 and 26.2° 2θ±0.2° 2θ; a DSC thermogram as depicted in FIG. 21 ; a solid state 13 C NMR spectrum having peaks at 146.4, 140.7, 136.3 and 117.3±0.2 ppm; and any combination thereof.
13. Crystalline Eltrombopag form XVI according to claim 11 , characterized by a powder XRD pattern having peaks at 7.1, 9.5, 13.9, 21.2 and 25.5° 2θ±0.2° 2θ.
14. A process for preparing Eltrombopag ethanolamine salt comprising preparing crystalline Eltrombopag according to any one of claims 1 - 13 and reacting the crystalline Eltrombopag with ethanolamine to obtain Eltrombopag ethanolamine salt.
15. The process according to claim 14 , wherein the Eltrombopag ethanolamine salt has a total purity of at least about 99%.
16. A crystalline form of Eltrombopag according to claim 1 , wherein at least one of (Z)-methyl 3′-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2′-hydroxybiphenyl-3-carboxylate and (Z)-3′-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2′-hydroxybiphenyl-3-carboxamide is present in an amount from about 0.01% to about 0.1% as measured by HPLC.
17. A pharmaceutical formulation comprising a crystalline form of Eltrombopag according to any one of claims 1 - 13 and 16 and at least one pharmaceutically acceptable excipient.