Marker delivery device with releasable plug
The invention is directed to marker delivery devices and methods of using such devices. The delivery devices embodying features of the invention include a delivery cannula with a discharge opening and a releasable plug disposed in the inner lumen of the delivery cannula so as to at least partially occlude the discharge opening. The releasable plug prevents ingress of tissue, body fluids and the like into the bore of the tube, and prevents the premature discharge of any markers proximal to the releasable plug from passing through the discharge opening before the distal end of the cannula is properly positioned at a desired location within a patient's body. The releasable plug preferably has an MRI detectable element. Preferably, at least one remotely detectable marker mass is provided in the inner lumen of the cannula proximal to the releasable plug.
1. An elongated intracorporeal remotely detectable marker body comprising a core of bioabsorbable fibers, an outer jacket surrounding at least part of the core comprising bioabsorbable fibers and a constricting element secured around the marker body.
2. The intracorporeal marker body of claim 1 wherein the constricting element radiopaque marker.
3. The intracorporeal marker body of claim 1 wherein the bioabsorbable fibers of the core comprise at least one material selected from the group consisting of oxidized cellulose, oxidized regenerated cellulose, polylactic acid, a copolymer of polylactic acid and glycolic acid, and polycaprolactone.
4. The intracorporeal marker body of claim 3 wherein the cellulose is oxidized, regenerated cellulose.
5. The intracorporeal marker body of claim 1 wherein the fibrous body is comprised of material which swells in the presence of body fluids or other water based fluids.
6. The intracorporeal marker body of claim 1 wherein the outer jacket is at least in part woven fabric.
7. The intracorporeal marker body of claim 1 in a compressed condition.
8. The intracorporeal marker body of claim 7 maintained in the compressed condition by having incorporated therein a binding agent.
9. The intracorporeal marker body of claim 8 wherein the binding agent is at least one water soluble polymer selected from the group consisting of polyvinyl alcohol, polyethylene glycol and polyvinyl pyrollidone.
10. The intracorporeal marker body of claim 1 including at least one bioactive component selected from the group consisting of therapeutic and diagnostic agents incorporated therein.
11. The intracorporeal marker body of claim 10 wherein the incorporated therapeutic or diagnostic agent is selected from the group consisting of a hemostatic agent, an anesthetic agent, a coloring agent, an antibiotic agent, an antifungal agent, an antiviral agent, a chemotherapeutic agent and a radioactive agent.
12. The intracorporeal marker body of claim 3 wherein the bioabsorbable material of the core includes oxidized cellulose and a material selected from the group consisting of polylactic acid, a co-polymer of polylactic acid and glycolic acid, polycaprolactone, collagen and mixtures thereof, including mixtures with the oxidized cellulose.
13. The intracorporeal marker body of claim 1 wherein the constricting element is disposed at a central portion thereof.
14. The intracorporeal marker body of claim 1 wherein the constricting element holds a portion of the body to prevent expansion thereof.
15. The intracorporeal marker body of claim 14 wherein the constricting element holds a central portion of the body to prevent expansion thereof.
16. The intracorporeal marker body of claim 15 wherein the body is configured to expand into a bow-tie shape when exposed to body fluid or other water based fluid.
17. The intracorporeal marker body of claim 1 wherein the constricting element is a radiopaque wire element clamped about a central exterior portion of the body.
18. The intracorporeal marker body of claim 7 which has been compressed at least 25%.
19. The intracorporeal marker body of claim 18 in a compressed bound condition.
20. The intracorporeal marker body of claim 19 which is bound by a binding agent selected from the group of water soluble polymers consisting of polyvinyl alcohol, polyethylene glycol and polyvinyl pyrollidone.
21. The intracorporeal marker body of claim 19 which is about 0.5 mm to about 12 mm in diameter.
22. The intracorporeal marker body of claim 19 which is about 1 to about 8 mm in diameter.
23. The intracorporeal marker body of claim 19 which is about 5 to about 30 mm in length.
24. The intracorporeal marker body of claim 19 which is about 10 to about 25 mm in length.
25. The intracorporeal marker body of claim 1 wherein the bioabsorbable fibers of the jacket comprise at least one material selected from the group consisting of oxidized cellulose, oxidized regenerated cellulose, polylactic acid, a copolymer of polylactic acid and glycolic acid, and polycaprolactone.
26. The intracorporeal marker body of claim 25 wherein the bioabsorbable material of the jacket includes oxidized cellulose and a material selected from the group consisting of polylactic acid, a co-polymer of polylactic acid and glycolic acid, polycaprolactone, collagen and mixtures thereof.