Needle driver for magnetic resonance elastography
The present invention is directed toward an acoustic, piezoelectric, electric, electro-mechanical or pneumatically driven surface drum driver, in mechanical engagement with a biopsy or acupuncture needle device and a method for its use for diagnosis of small e.g. 100 microns, tumors via the production of magnetic resonance elastographic images (MRE), without artifact production, in a magnetic resonance imaging (MRI) machine. In a second embodiment, the invention is directed toward an acoustically, pneumatically, piezoelectrically, electrically and/or electro-mechanically driven acupuncture needle, useful for simulating manual single-needle acupuncture treatments via a non-manually manipulated acupuncture needle; and further to a device and process for determination, using twin pneumatically driven surface drivers, of organ stiffness, e.g. brain stiffness, which can be quantified so as to be useful in elucidating and quantifying brain cognitive state, e.g. normal, mild cognitive impairment (MCI) or Alzheimer's dementia (AD).
1. A process to establish a standard range of brain viscosity and elasticity in normal subjects, Mild Cognitive Impairment (MCI) patients and Alzheimer's Disease (AD) patients comprising:
positioning a patient within a magnetic resonance imaging (MRI) device;
providing a pair of pneumatic drum drivers useful within said MRI device, each driven synchronously by a single wave generator;
positioning said pair of pneumatic drum drivers in contact with the patient's skull, thereby simultaneously generating a shear wave, and a corresponding interference wave effective to neutralize attenuation of said shear wave, each wave propagating in the brain;
elucidating brain stiffness data as a function of shear wavelength; and
establishing a standard range of brain viscosity and elasticity in normal subjects, MCI patients and AD patients;
and correlating changes in brain viscosity and elasticity between normal, MCI and AD patients.
2. A process for generating magnetic resonance elastographs of cancerous tumors comprising:
positioning a patient within a magnetic resonance imaging (MRI) device;
providing a first acoustic, piezoelectric, electric, electro-mechanical or pneumatically driven surface drum driver, useful within said MRI device, in mechanical engagement with a biopsy or acupuncture needle;
providing a second acoustic, piezoelectric, electric, electro-mechanical or pneumatically driven surface drum driver in contact with said patient, in an area adjacent said acupuncture or biopsy needle;
inserting said biopsy or acupuncture needle within a tissue suspected of containing a cancerous tumor;
providing wave generating means for synchronous movement of said biopsy or acupuncture needle within said tissue, wherein both spherical and plane waves are generated, thereby enhancing specificity and sensitivity; and
generating a magnetic resonance elastograph.
3. The process of claim 2 , further including the act of conducting a biopsy by use of the biopsy needle.