Compounds and methods for the treatment or prevention of
The present invention provides novel compounds represented by formula I: or pharmaceutically acceptable salts thereof useful for treating flaviviridae viral infection.
1. A compound having the formula (I):
or a pharmaceutically acceptable salt thereof;
wherein,
X is
M is
J is
Y 1 is a bond;
Y is COOH;
R 1 is C 2-12 alkyl, C 2-12 alkenyl, C 2 alkynyl, C 6-14 aryl, C 3-12 heterocycle, C 3-18 heteroaralkyl or C 6-18 aralkyl;
R 2 is C 2-12 alkyl, C 2-12 alkenyl, C 2-12 alkynyl, C 6-14 aryl, C 3-12 heterocycle, C 3-18 heteroaralkyl, or C 6-18 aralkyl;
R 3 is H, C 1-12 alkyl, C 2-12 alkenyl, C 2 alkynyl, C 6-14 aryl, C 3-12 heterocycle, C 3-18 heteroaralkyl or C 6-18 aralkyl; and
Z is H, halogen, or C 1-6 alkyl;
with the proviso that: when X is Benzamide and R 1 is phenyl, then R 3 is other than hydrogen;
wherein
alkyl in R 1 , R 2 , R 3 , and Z is in each case optionally substituted by one or more of: halogen, nitro, nitroso, SO 3 R 12 , PO 3 R c R d , CONR 13 R 14 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-12 aralkyl, C 6-12 aryl, C 1-6 alkyloxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, C 6-12 aryloxy, C(O)C 1-6 alkyl, C(O)C 2-6 alkenyl, C(O)C 2-6 alkynyl, C(O)C 6-12 aryl, C(O)C 6-12 aralkyl, C 3-10 heterocycle, hydroxyl, NR 13 R 14 , C(O)OR 12 , cyano, azido, amidino or guanido;
alkenyl in R 1 , R 2 , and R 3 is in each case optionally substituted by one or more of: halogen, nitro, nitroso, SO 3 R 12 , PO 3 R c R d , CONR 13 R 14 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-12 aralkyl, C 6-12 aryl, C 1-6 alkyloxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, C 6-12 aryloxy, C(O)C 1-6 alkyl, C(O)C 2-6 alkenyl, C(O)C 2-6 alkynyl, C(O)C 6-12 aryl, C(O)C 6-12 aralkyl, C 3-10 heterocycle, hydroxyl, NR 13 R 14 , C(O)OR 12 , cyano, azido, amidino or guanido;
alkynyl in R 1 , R 2 , and R 3 is in each case optionally substituted by one or more of:: halogen, nitro, nitroso, SO 3 R 12 , PO 3 R c R d , CONR 13 R 14 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-12 aralkyl, C 6-12 aryl, C 1-6 alkyloxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, C 6-12 aryloxy, C(O)C 1-6 alkyl, C(O)C 2-6 alkenyl, C(O)C 2-6 alkynyl, C(O)C 6-12 aryl, C(O)C 6-12 aralkyl, C 3-10 heterocycle, hydroxyl, NR 13 R 14 , C(O)OR 12 , cyano, azido, amidino or guanido;
aryl in R 1 , R 2 , and R 3 is in each case optionally substituted by one or more of: halogen, nitro, nitroso, SO 3 R 12 , PO 3 R c R d , CONR 13 R 14 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-12 aralkyl, C 6-12 aryl, C 1-6 alkyloxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, C 6-12 aryloxy, C(O)C 1-6 alkyl, C(O)C 2-6 alkenyl, C(O)C 2-6 alkynyl, C(O)C 6-12 aryl, C(O)C 6-12 aralkyl, C 3-10 heterocycle, hydroxyl, NR 13 R 14 , C(O)OR 12 , cyano, azido, amidino or guanido;
aralkyl in R 1 , R 2 , and R 3 is in each case an aryl group attached to the adjacent atom by a C 1-6 alkyl, C 2-6 alkenyl, or C 2-6 alkynyl, and the aryl group is in each case optionally substituted by one or more of: halogen, nitro, nitroso, SO 3 R 12 , PO 3 R c R d , CONR 13 R 14 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-12 aralkyl, C 6-12 aryl, C 1-6 alkyloxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, C 6-12 aryloxy, C(O)C 1-6 alkyl, C(O)C 2-6 alkenyl, C(O)C 2-6 alkynyl, C(O)C 6-12 aryl, C(O)C 6-12 aralkyl, C 3-10 heterocycle, hydroxyl, NR 13 R 14 , C(O)OR 12 , cyano, azido, amidino or guanido;
heterocycle in R 1 , R 2 , and R 3 is in each case optionally substituted by one or more of: halogen, nitro, nitroso, SO 3 R 12 , PO 3 R c R d , CONR 13 R 14 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-12 aralkyl, C 6-12 aryl, C 1-6 alkyloxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, C 6-12 aryloxy, C(O)C 1-6 alkyl, C(O)C 2-6 alkenyl, C(O)C 2-6 alkynyl, C(O)C 6-12 aryl, C(O)C 6-12 aralkyl, C 3-10 heterocycle, hydroxyl, NR 13 R 14 , C(O)OR 12 , cyano, azido, amidino or guanido;
heteroaralkyl in R 1 , R 2 , and R 3 in each case an heterocycle group attached to the adjacent atom by a C 1-6 alkyl, C 2-6 alkenyl, or C 2-6 alkynyl, and the heterocycle group is in each case optionally substituted by one or more of: halogen, nitro, nitroso, SO 3 R 12 , PO 3 R c R d , CONR 13 R 14 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-12 aralkyl, C 6-12 aryl, C 1-6 alkyloxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, C 6-12 aryloxy, C(O)C 1-6 alkyl, C(O)C 2-6 alkenyl, C(O)C 2-6 alkynyl, C(O)C 6-12 aryl, C(O)C 6-12 aralkyl, C 3-10 heterocycle, hydroxyl, NR 13 R 14 , C(O)OR 12 , cyano, azido, amidino or guanido; and
R 12 , R c , R d , R 13 and R 14 , are each independently H, C 1-12 alkyl, C 2-12 alkenyl, C 2-12 alkynyl, C 6-14 aryl, C 3-12 heterocycle, C 3-18 heteroaralkyl, or C 6-18 aralkyl, or R c and R d are taken together with the oxygens to form a 5 to 10 membered heterocycle, or R 13 and R 14 are taken together with the nitrogen to form a 3 to 10 membered heterocycle,
in each case above alkyl groups include alkyls in which one or more hydrogen atoms are each replaced by a halogen, and
sulfur atoms are in the form of S, SO, or SO 2 .
2. A compound according to claim 1 , wherein said compound is of formula Ia:
or a pharmaceutically acceptable salt thereof.
3. A compound according to claim 1 , wherein X is
4. A compound according to claim 1 , wherein Z is H.
5. A compound according to claim 1 , wherein R 1 is C 2-12 alkyl, C 6-14 aryl, or C 3-12 heterocycle, which in each case is substituted or unsubstituted.
6. A compound according to claim 1 , wherein R 3 is H, C 1-12 alkyl, C 6-18 aralkyl, C 3-12 heterocycle, or C 3-18 heteroaralkyl, which in each case is substituted or unsubstituted.
7. A compound according to claim 6 , wherein R 3 is C 1-12 alkyl which is substituted or unsubstituted.
8. A compound according to claim 1 , wherein
R 3 is H, or R 3 is methyl, ethyl, isopropyl, cyclopropyl, cyclohexyl, allyl, piperidinyl, piperazinyl, pyrrolidinyl, azetidinyl, aziridinyl, pyridinyl, piperidinylmethyl, dioxanyl, azepanyl or benzyl, which in each case is unsubstituted or substituted by one or more substituents chosen from halogen, nitro, nitroso, SO 3 R 12 , PO 3 R c R d , CONR 13 R 14 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-12 aralkyl, C 6-12 aryl, C 1-6 alkyloxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, C 6-12 aryloxy, C(O)C 1-6 alkyl, C(O)C 2-6 alkenyl, C(O)C 2-6 alkynyl, C(O)C 6-12 aryl, C(O)C 6-12 aralkyl, C 3-10 heterocycle, hydroxyl, NR 13 R 14 , C(O)OR 12 , cyano, azido, amidino or guanido; and
R 12 , R c , R d , R 13 and R 14 are each independently H, C 1-12 alkyl, C 2-12 alkenyl, C 2-12 alkynyl, C 6-14 aryl, C 3-12 heterocycle, C 3-18 heteroaralkyl, or C 6-18 aralkyl,
or R c and R d , taken together with the oxygens, form a 5 to 10 membered heterocycle,
or R 13 and R 14 , taken together with the nitrogen, form a 3 to 10 membered heterocycle.
9. A compound according to claim 1 , wherein R 3 is H, or R 3 is methyl, isopropyl, piperidinyl, piperidinylmethyl, dioxolanyl or cyclohexyl, which in each case is substituted or unsubstituted by one or more substituents chosen from halogen, nitro, nitroso, SO 3 R 12 , PO 3 R c R d , CONR 13 R 14 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-12 aralkyl, C 6-12 aryl, C 1-6 alkyloxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, C 6-12 aryloxy, C(O)C 1-6 alkyl, C(O)C 2-6 alkenyl, C(O)C 2-6 alkynyl, C(O)C 6-12 aryl, C(O)C 6-12 aralkyl, C 3-10 heterocycle, hydroxyl, NR 13 R 14 , C(O)OR 12 , cyano, azido, amidino or guanido; and
R 12 , R c , R d , R 13 and R 14 are each independently H, C 1-12 alkyl, C 2-12 alkenyl, C 2-12 alkynyl, C 6-14 aryl, C 3-12 heterocycle, C 3-18 heteroaralkyl, or C 6-18 aralkyl,
or R c and R d , taken together with the oxygens, form a 5 to 10 membered heterocycle,
or R 13 and R 14 , taken together with the nitrogen, form a 3 to 10 membered heterocycle.
10. A compound according to claim 9 , wherein R 3 is isopropyl which is substituted or unsubstituted.
11. A compound according to claim 9 , wherein R 3 is cyclohexyl which is substituted or unsubstituted.
12. A compound according to claim 1 , wherein R 2 is C 2-12 alkyl, C 6-14 aryl, or C 3-12 heterocycle, which in each case is substituted or unsubstituted.
13. A compound according to claim 2 , wherein R 2 is C 2-12 alkyl which is substituted or unsubstituted.
14. A compound according to claim 1 , wherein
R 2 is cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl cyclohexyl, cycloheptyl, 2-(cyclopentyl)-ethyl, ethyl, vinyl, propyl, propenyl, isopropyl, butyl, butenyl isobutyl, pentyl, neopentyl or t-butyl, which in each case is unsubstituted or substituted by one or more substituents chosen from halogen, nitro, nitroso, SO 3 R 12 , PO 3 R c R d , CONR 13 R 14 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-12 aralkyl, C 6-12 aryl, C 1-6 alkyloxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, C 6-12 aryloxy, C(O)C 1-6 alkyl, C(O)C 2-6 alkenyl, C(O)C 2-6 alkynyl, C(O)C 6-12 aryl, C(O)C 6-12 aralkyl, C 3-10 heterocycle, hydroxyl, NR 13 R 14 , C(O)OR 12 , cyano, azido, amidino or guanido; and
R 12 , R c , R d , R 13 and R 14 are each independently H, C 1-12 alkyl, C 2-12 alkenyl, C 2-12 alkynyl, C 6-14 aryl, C 3-12 heterocycle, C 3-18 heteroaralkyl, or C 6-18 aralkyl,
or R c and R d , taken together with the oxygens, form a 5 to 10 membered heterocycle,
or R 13 and R 14 , taken together with the nitrogen, form a 3 to 10 membered heterocycle.
15. A compound according to claim 2 , wherein X is
16. A compound according to claim 2 , wherein Z is H.
17. A compound according to claim 2 , wherein R 1 is C 2-12 alkyl, C 6-14 aryl, or C 3-12 heterocycle, which in each case is substituted or unsubstituted.
18. A compound according to claim 2 , wherein R 3 is H, or R 3 is C 1-12 alkyl, C 6-18 aralkyl, C 3-12 heterocycle, or C 3-18 heteroaralkyl, which in each case is substituted or unsubstituted.
19. A compound according to claim 18 , wherein R 3 is C 1-12 alkyl which is substituted or unsubstituted.
20. A compound according to claim 2 , wherein
R 3 is H, or R 3 is methyl, ethyl, isopropyl, cyclopropyl, cyclohexyl, allyl, piperidinyl, piperazinyl, pyffolidinyl, azetidinyl, aziridinyl, pyridinyl, piperidinylmethyl, dioxanyl, azepanyl or benzyl, which in each case is unsubstituted or substituted by one or more substituents chosen from halogen, nitro, nitroso, S 03 R 12 , PO 3 RRd, C 0 NR 13 R 14 , C 16 alkyl, C 26 alkenyl, C 26 alkynyl, C 6 i 2 aralkyl, C 612 aryl, Ci 6 alkyloxy, C 26 alkenyloxy, C 26 alkynyloxy, C 62 aryloxy, C(O)C 16 alkyl, C(O)C 26 alkenyl, C(O)C 26 alkynyl, C(O)C 612 aryl, C(O)C 612 aralkyl, C 3 ioheterocycle, hydroxyl, NR 13 R 14 , C(O) 0 R 12 , cyano, azido, amidino, and guanido; and R 12 , R, Rd, R 13 and R 14 are each independently H, C 112 alkyl, C 212 alkenyl, C 212 alkynyl, C 614 aryl, C 3 i 2 heterocycle, C 3 i 8 heteroaralkyl, or C 6 i 8 aralkyl, or R and Rd, taken together with the oxygens, form a 5 to 10 membered heterocycle, SO 3 R 12 , PO 3 R c R d , CONR 13 R 14 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-12 aralkyl, C 6-12 aryl, C 1-6 alkyloxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, C 6-12 aryloxy, C(O)C 1-6 alkyl, C(O)C 2-6 alkenyl, C(O)C 2-6 alkynyl, C(O)C 6-12 aryl, C(O)C 6-12 aralkyl, C 3-10 heterocycle, hydroxyl, NR 13 R 14 , C(O)OR 12 , cyano, azido, amidino or guanido; and
R 12 , R c , R d , R 13 and R 14 are each independently H, C 1-12 alkyl, C 2-12 alkenyl, C 2-12 alkynyl, C 6-14 aryl, C 3-12 heterocycle, C 3-18 heteroaralkyl, or C 6-18 aralkyl,
or R c and R d , taken together with the oxygens, form a 5 to 10 membered heterocycle,
or R 13 and R 14 , taken together with the nitrogen, form a 3 to 10 membered heterocycle.
21. A compound according to claim 2 , wherein R 3 is H or R 3 is methyl, isopropyl, piperidinyl, piperidinylmethyl, dioxolanyl or cyclohexyl, which in each case is substituted or unsubstituted.
22. A compound according to claim 21 , wherein R 3 is isopropyl which is substituted or unsubstituted.
23. A compound according to claim 21 , wherein R 3 is cyclohexyl which is substituted or unsubstituted.
24. A compound according to claim 2 , wherein R 2 is C 2-12 alkyl, C 6-14 aryl, or C 3-12 heterocycle, which in each case is substituted or unsubstituted.
25. A compound according to claim 24 , wherein R 2 is C 2-12 alkyl which is substituted or unsubstituted.
26. A compound according to claim 2 , wherein
R 2 is cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl cyclohexyl, cycloheptyl, 2-(cyclopentyl)-ethyl, ethyl, vinyl, propyl, propenyl, isopropyl, butyl, butenyl isobutyl, pentyl, neopentyl or t-butyl, which in each case is unsubstituted or substituted by one or more substituents chosen from halogen, nitro, nitroso, SO 3 R 12 , PO 3 R c R d , CONR 13 R 14 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-12 aralkyl, C 6-12 aryl, C 1-6 alkyloxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, C 6-12 aryloxy, C(O)C 1-6 alkyl, C(O)C 2-6 alkenyl, C(O)C 2-6 alkynyl, C(O)C 6-12 aryl, C(O)C 6-12 aralkyl, C 3-10 heterocycle, hydroxyl, NR 13 R 14 , C(O)OR 12 , cyano, azido, amidino or guanido; and
R 12 , R c , R d , R 13 and R 14 are each independently H, C 1-12 alkyl, C 2-12 alkenyl, C 2-12 alkynyl, C 6-14 aryl, C 3-12 heterocycle, C 3-18 heteroaralkyl, or C 6-18 aralkyl,
or R c and R d , taken together with the oxygens, form a 5 to 10 membered heterocycle,
or R 13 and R 14 , taken together with the nitrogen, form a 3 to 10 membered heterocycle.
27. A compound according to claim 2 , wherein Z is H and X is
28. A compound according to claim 27 , wherein
R 1 is C 2-12 alkyl, C 6-14 aryl, or C 3-12 heterocycle, which in each case is substituted or unsubstituted;
R 3 is H, or R 3 is C 1-12 alkyl, C 6-18 aralkyl, C 3-12 heterocycle, or C 3-18 heteroaralkyl, which in each case is substituted or unsubstituted; and
R 2 is C 2-12 alkyl, C 6-14 aryl, or C 3-12 heterocycle, which in each case is substituted or unsubstituted.
29. A compound according to claim 27 , wherein R 3 is C 1-12 alkyl and R 2 is C 2-12 alkyl, which in each case is substituted or unsubstituted.
30. A compound according to claim 28 , wherein R 3 is C 1-12 alkyl and R 2 is C 2-12 alkyl, which in each is substituted or unsubstituted.
31. A compound according to claim 27 , wherein
R 3 is H, or R 3 is methyl, ethyl, isopropyl, cyclopropyl, cyclohexyl, allyl, piperidinyl, piperazinyl, pyffolidinyl, azetidinyl, aziridinyl, pyridinyl, piperidinylmethyl, dioxanyl, azepanyl or benzyl, which in each case is unsubstituted or substituted by one or more substituents chosen from halogen, nitro, nitroso, SO 3 R 12 , PO 3 R c R d , CONR 13 R 14 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-12 aralkyl, C 6-12 aryl, C 1-6 alkyloxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, C 6-12 aryloxy, C(O)C 1-6 alkyl, C(O)C 2-6 alkenyl, C(O)C 2-6 alkynyl, C(O)C 6-12 aryl, C(O)C 6-12 aralkyl, C 3-10 heterocycle, hydroxyl, NR 13 R 14 , C(O)OR 12 , cyano, azido, amidino or guanido;
R 2 is cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl cyclohexyl, cycloheptyl, 2-(cyclopentyl)-ethyl, ethyl, vinyl, propyl, propenyl, isopropyl, butyl, butenyl isobutyl, pentyl, neopentyl or t-butyl, which in each case is unsubstituted or substituted by one or more substituents chosen from halogen, nitro, nitroso, SO 3 R 12 , PO 3 R c R d , CONR 13 R 14 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-12 aralkyl, C 6-12 aryl, C 1-6 alkyloxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, C 6-12 aryloxy, C(O)C 1-6 alkyl, C(O)C 2-6 alkenyl, C(O)C 2-6 alkynyl, C(O)C 6-12 aryl, C(O)C 6-12 aralkyl, C 3-10 heterocycle, hydroxyl, NR 13 R 14 , C(O)OR 12 , cyano, azido, amidino or guanido; and
R 12 , R c , R d , R 13 and R 14 are each independently H, C 1-12 alkyl, C 2-12 alkenyl, C 2-12 alkynyl, C 6-14 aryl, C 3-12 heterocycle, C 3-18 heteroaralkyl, or C 6-18 aralkyl,
or R c and R d , taken together with the oxygens, form a 5 to 10 membered heterocycle,
or R 13 and R 14 , taken together with the nitrogen, form a 3 to 10 membered heterocycle.
32. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 1 .
33. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 2 .
34. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 3 .
35. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 4 .
36. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 5 .
37. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 6 .
38. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 7 .
39. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 8 .
40. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 9 .
41. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 10 .
42. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 11 .
43. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 12 .
44. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 13 .
45. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 14 .
46. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 15 .
47. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 16 .
48. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 17 .
49. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 18 .
50. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 19 .
51. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 20 .
52. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 21 .
53. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 22 .
54. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 23 .
55. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 24 .
56. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 25 .
57. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 26 .
58. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 27 .
59. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 28 .
60. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 30 .
61. A method for treating a Hepatitis C virus (HCV) infection in a host comprising administering to the host a therapeutically effective amount of at least one compound according to claim 31 .