C-linked glucuronide of N-(4-hydroxybenzyl) retinone, analogs thereof, and method of using the same to inhibit neoplastic cell growth

1. A compound of Formula I:

wherein X is CH 2 ; Y is C 1 -C 6 alkylene; R is C 1 -C 6 alkyl; and R 2 is selected from the group consisting of H and ═O;

or a salt thereof.

2. A pharmaceutical composition for inhibiting formation of breast cancer and treating breast cancer in mammals, the composition comprising an effective cancer cell growth-inhibiting amount of a compound according to claim 1 , or a pharmaceutically-suitable salt thereof, optionally in combination with a pharmaceutically-suitable carrier.

3. A method of inhibiting formation of breast cancer and treating breast cancer in mammals, the method comprising administering a cancer cell growth-inhibiting amount of a compound according to claim 1 , or a pharmaceutically-suitable salt thereof, to a patient in need thereof.

4. A compound of Formula I:

wherein X is CH 2 ; Y is C 1 -C 6 alkylene; and R is selected from the group consisting of hydrogen, C 1 -C 6 alkyl, and

wherein R 1 is selected from the group consisting of OH, C 1 -C 6 alkyl, alkenyl, and alkynyl; and R 2 is selected from the group consisting of H and ═O;

or a salt thereof.

5. A pharmaceutical composition for inhibiting formation of breast cancer and treating breast cancer in mammals, the composition comprising an effective cancer cell growth-inhibiting amount of a compound according to claim 4 , or a pharmaceutically-suitable salt thereof, optionally in combination with a pharmaceutically-suitable carrier.

6. A method of inhibiting formation of breast cancer and treating breast cancer in mammals, the method comprising administering a cancer cell growth-inhibiting amount of a compound according to claim 4 , or a pharmaceutically-suitable salt thereof, to a patient in need thereof.