Mutations in OAS1 genes
Modified amino acid sequences of OAS1 proteins in non-human primates, and genes related thereto, are provided.
1. An isolated oligoadenylate synthetase 1 protein consisting of the amino acid sequence of SEQ ID NO:1, except the methionine at position 1 is deleted, and the amino acid at position 162 is glycine.
2. A therapeutic composition for treating infection by a virus in a mammal wherein said composition comprises a pharmaceutically acceptable carrier and the oligoadenylate synthetase 1 protein of claim 1 .
3. A therapeutic composition of claim 2 wherein the virus is hepatitis C virus.
4. A therapeutic composition of claim 2 wherein the virus is a flavivirus.
5. A method for treating a viral infection in a mammalian subject which comprises providing to a subject in need of such treatment the therapeutic composition of claim 2 .
6. A kit comprising the composition therapeutic of claim 2 .
7. The kit of claim 6 wherein the kit includes one or more of instructions for using the therapeutic composition or a label or insert indicating regulatory approval for use of the therapeutic composition.