Use of liver X receptor agonists
The present invention generally relates to a novel therapeutical use of liver X receptor (LXR) agonsits. More specifically, the present invention relates to the use of LXR agonist for the preparation of a medicament useful for the treatment and/or the prevention of a disease associated with beta cells degeneration, such as diabetes, and a method for increasing ex vivo viability of pancreatic islet cells, comprising contacting said islet cells with a LXR agonist.
1. A method of treating or inhibiting type I diabetes, said method comprising administering to a subject in need thereof a therapeutically effective amount of an LXR agonist selected from the group consisting of GW3965 and T0901317.
2. A method as claimed in claim 1 , wherein the administering of the LXR agonist produces regeneration of beta cells.
3. A method as claimed in claim 1 , wherein the administering of the LXR agonist produces an increase in viability of beta cells.
4. A method as claimed in claim 1 , wherein said subject is a transplant recipient of transplanted donor pancreatic islet cells, and the administering of the LXR agonist produces an increase in viability of the transplanted donor pancreatic islet cells in the subject.
5. A method as claimed in claim 1 , wherein the LXR agonist is administered orally.
6. A method as claimed in claim 1 , wherein the LXR agonist is administered daily for at least 30 days.
7. A method of treating type I diabetes in a subject suffering therefrom, said method comprising
measuring circulating glucose level, or HbA1c level, or both, in the subject;
administering daily to the subject a therapeutically effective amount of an LXR, agonist selected from the group consisting of GW3965 and T0901317 until the measured circulating glucose level is maintained at a glucose target value less than or equal to 1.4 g/l, or until the measured HbA1c level is maintained at an HbA1c target value less than or equal to 7%, or both, for one month with at least two dosages;
thereafter stopping the administration of the LXR agonist; and
optionally recommencing the administration of the LXR agonist if the measured glucose level or HbA1c level exceeds either or both of the respective target values.
8. A method as claimed in claim 7 , wherein the circulating glucose target value is less than or equal to 1.2 g/l.