Thermal treatment of a drug eluting implantable medical device
A coating and a method of coating an implantable medical device, such as a stent, is disclosed. The method includes subjecting the coating to a thermal condition such as a temperature above the glass transition temperature of a polymer included in the coating.
1. A method of manufacturing a drug delivery stent, the method comprising:
forming a dry polymeric coating on a stent having less than about 2% residual fluid content (w/w), the dry polymeric coating comprising a reservoir layer comprising a polymer and an active agent, and a barrier layer comprising a polymer covering a portion of the reservoir layer; and
subjecting the polymer of the barrier layer to a heat treatment at a temperature equal to or greater than the glass transition of the polymer of the barrier layer;
wherein the polymer of the barrier layer comprises an ethylene vinyl alcohol copolymer, an ethylene-vinyl acetate copolymer, poly(butylmethacrylate), or a combination thereof.
2. The method of claim 1 , wherein the active agent is rapamycin, 40-O-(2-hydroxy)ethyl-rapamycin, or a functional analog or structural derivative thereof.
3. The method of claim 1 , wherein the glass transition temperature of the polymer of the barrier layer is greater than the glass transition temperature of the polymer of the reservoir layer.
4. The method of claim 1 , wherein the glass transition temperature of the polymer of the barrier layer is lower than the glass transition temperature of the polymer of the reservoir layer.
5. The method of claim 1 , wherein the glass transition temperature of the polymer of the barrier layer is about the same as the glass transition temperature of the polymer of the reservoir layer.
6. The method of claim 1 , wherein the temperature of the heat treatment is less than the melting temperature of the polymer of the barrier layer.
7. The method of claim 1 , wherein the temperature of the heat treatment is less than the melting temperature of the polymer of the reservoir layer.
8. The method of claim 1 , wherein the temperature of the heat treatment is equal to the glass transition temperature of the polymer of the barrier layer plus the melting temperature of the polymer of the barrier layer, divided by 2.
9. The method of claim 1 , wherein the temperature of the heat treatment is equal to 0.9 times the melting temperature of the polymer of the barrier layer, wherein the melting temperature of the polymer of the barrier layer is expressed in Kelvin.
10. The method of claim 1 , wherein the glass transition temperature of the polymer of the barrier layer is above room temperature.
11. A method of manufacturing a drug delivery stent, the method comprising:
forming a polymeric coating on a stent, the polymeric coating comprising a reservoir layer comprising a polymer and an active agent, and a barrier layer comprising a semicrystalline polymer covering a portion of the reservoir layer; and
exposing the polymer of the barrier layer to the crystallization temperature of The polymer of the barrier layer.
12. The method of claim 11 , wherein the polymeric coating comprises less than about 2% residual fluid content (w/w).
13. The method of claim 11 , wherein the active agent is rapamycin, 40-O-(2-hydroxy)ethyl-rapamycin, or a functional analog or structural derivative thereof.
14. The method of claim 11 , wherein the polymer of the reservoir layer is a semicrystalline polymer and wherein the crystallization temperature of the polymer of the barrier layer is greater than the crystallization temperature of the polymer of the reservoir layer.
15. The method of claim 11 wherein the polymer of the reservoir layer is a semicrystalline polymer and wherein the crystallization temperature of the polymer of the barrier layer is less than the crystallization temperature of the polymer of the reservoir layer.
16. The method of claim 11 , wherein the polymer of the reservoir layer is a semicrystalline polymer and wherein the crystallization temperature of the polymer of the barrier layer is equal to the crystallization temperature of the polymer of the reservoir layer.
17. A method of manufacturing a drug delivery stent, the method comprising:
forming a dry polymeric coating on a stent having less than about 2% residual fluid content (w/w), the dry polymeric coating comprising a reservoir layer comprising a polymer and an active agent, and a barrier layer comprising a polymer covering a portion of the reservoir layer; and
subjecting the polymer of the barrier layer to a heat treatment at a temperature equal to or greater than the glass transition of the polymer of the barrier layer;
wherein the glass transition temperature of the polymer of the barrier layer is greater than the glass transition temperature of the polymer of the reservoir layer.
18. A method of manufacturing a drug delivery stent, the method comprising:
forming a dry polymeric coating on a stent having less than about 2% residual fluid content (w/w), the dry polymeric coating comprising a reservoir layer comprising a polymer and an active agent, and a barrier layer comprising a polymer covering a portion of the reservoir layer; and
subjecting the polymer of the barrier layer to a heat treatment at a temperature equal to or greater than the glass transition of the polymer of the barrier layer;
wherein the glass transition temperature of the polymer of the barrier layer is lower than the glass transition temperature of the polymer of the reservoir layer.
19. A method of manufacturing a drug delivery stent, the method comprising:
forming a dry polymeric coating on a stent having less than about 2% residual fluid content (w/w), the dry polymeric coating comprising a reservoir layer comprising a polymer and an active agent, and a barrier layer comprising a polymer covering a portion of the reservoir layer; and
subjecting the polymer of the barrier layer to a heat treatment at a temperature equal to or greater than the glass transition of the polymer of the barrier layer;
wherein the temperature is equal to 0.9 times the melting temperature of the polymer of the barrier layer, wherein the melting temperature of the polymer of the barrier layer is expressed in Kelvin.