Method for inhibiting AGE complex formation
Various methods of administering medication(s) that inhibit the nonenzymatic formation of glycation and dehydration condensation complexes known as advanced glycation end-products (AGEs) or modulate the advanced glycation end-product receptor (RAGE) are provided. Also, a medication releasing medical devices, wherein at least a portion of the medical device releasably includes at least one of these medication(s) are provided.
1. A method of inhibiting the nonenzymatic formation of glycation and dehydration condensation complexes known as advanced glycation end-products (AGE), said method comprising administering to a subject in need of inhibition of advanced glycation end products (AGE), said method comprising administering to a subject in need of inhibition of advanced glycation end product formation at least one medication that inhibits the nonenzymatic formation of AGE complexes wherein said agent is associated with a medical device selected from the group consisting of deposition implants, and medication delivery pumps, and said medication is selected from the group consisting of pyridoxamine, N-phenacylthazolium bromide, alagebrium, and combinations thereof.
2. The method according to claim 1 wherein said medication further comprises at least one inert pharmaceutical excipient.
3. The method according to claim 1 wherein said medication comprises a controlled-release profile.
4. The method according to claim 1 wherein said subject is suffering from diabetes and presents an elevated level of glycosylated hemoglobin in the blood.
5. The method according to claim 1 wherein said subject is suffering from kidney disease and presents an elevated level of protein in the urine.
6. The method according to claim 1 wherein said subject is suffering from atherosclerosis and presents an elevated level of cholesterol in the blood.
7. The method according to claim 1 wherein the medical device is a medication delivery pump.