Urea derivative and process for preparing the same
A process for preparing a compound (C) represented by the following formula: wherein R 1 represents hydrogen, C 1-6 alkyl or C 3-8 cycloalkyl, and R 2 represents hydrogen or methoxy, characterized by reacting a compound (A-1) represented by the following formula: wherein R 1 has the same definition as above, with a compound (B) represented by the following formula: wherein R 2 has the same definition as above, and L represents a leaving group, is provided. Compound (C) is effective for prevention or treatment of various diseases associated with angiogenesis neoplasia.
1. A compound (A-1) or a salt thereof or a hydrate of the foregoing represented by the following formula:
wherein R 1 represents hydrogen, C 1-6 alkyl or C 3-8 cycloalkyl.
2. A compound or a salt thereof or a hydrate of the foregoing according to claim 1 , wherein R 1 is hydrogen, methyl, ethyl, n-propyl or cyclopropyl.
3. A compound or a salt thereof or a hydrate of the foregoing according to claim 1 , wherein R 1 is cyclopropyl.
4. A compound (A-2) or a salt thereof or a hydrate of the foregoing represented by the following formula:
wherein Ar represents C 6-10 aryl optionally having 1 or 2 substituents selected from the group consisting of halogen, methyl, methoxy and nitro.
5. A compound or a salt thereof or a hydrate of the foregoing according to claim 4 , wherein Ar is phenyl.