Patent
The present invention relates to the field of vaccination against Salmonella in animals, particularly avian animals. The present invention also encompasses kits and uses of Salmonella immunogenic compositions or vaccines. The present invention further relates to methods and compositions comprising at least one primo-administration of an attenuated immunogenic composition or vaccine, comprising a pharmaceutically or veterinarily acceptable excipient, diluent or vehicle and at least one attenuated Salmonella , administered to an avian animal before at least one boost-administration of an inactivated immunogenic composition or vaccine, comprising a pharmaceutically or veterinarily acceptable excipient, diluent or vehicle, and at least one inactivated Salmonella.
1. A method comprising:
at least one primo-administration of an attenuated immunogenic composition or vaccine, comprising a pharmaceutically or veterinarily acceptable excipient, diluent or vehicle and at least one attenuated Salmonella , administered to an avian animal before at least one boost-administration of an inactivated immunogenic composition or vaccine, comprising a pharmaceutically or veterinarily acceptable excipient, diluent or vehicle, and at least one inactivated Salmonella,
wherein the primo-administration and boost-administration are administered between 3 and 10 weeks apart.
2. A method comprising:
at least one primo-administration of an inactivated immunogenic composition or vaccine, comprising a pharmaceutically or veterinarily acceptable excipient, diluent or vehicle and at least one inactivated Salmonella , administered to an avian animal before at least one boost-administration of an attenuated immunogenic composition or vaccine, comprising a pharmaceutically or veterinarily acceptable excipient, diluent or vehicle, and at least one attenuated Salmonella,
wherein the primo-administration and boost-administration are administered between 3 and 10 weeks apart.
3. The method of claim 1 , wherein the at least one attenuated Salmonella or the at least one inactivated Salmonella is selected from the Salmonella B group.
4. The method of claim 3 , wherein the Salmonella B group comprises Salmonella Typhimurium, Salmonella Braenderup, Salmonella Agona, Salmonella Bredeney, Salmonella Heidelberg, Salmonella Indiana, Salmonella Saint-Paul, Salmonella Brandenburg.
5. The method of claim 4 , wherein the at least one attenuated Salmonella or the least one inactivated Salmonella of the Salmonella B group is Salmonella Typhimurium.
6. The method of claim 1 , wherein the at least one attenuated Salmonella or the at least one inactivated Salmonella is selected from the Salmonella D group.
7. The method of claim 6 , wherein the Salmonella D group comprises Salmonella Enteritidis, Salmonella Panama, Salmonella Dublin, Salmonella Gallinarum, Salmonella Pullorum.
8. The method of claim 7 , wherein the at least one attenuated Salmonella or the at least one inactivated Salmonella of the Salmonella D group is Salmonella Enteritidis.
9. The method of claim 2 , wherein the at least one attenuated Salmonella or the at least one inactivated Salmonella is selected from the Salmonella B group.
10. The method of claim 9 , wherein the Salmonella B group comprises Salmonella Typhimurium, Salmonella Braenderup, Salmonella Agona, Salmonella Bredeney, Salmonella Heidelberg, Salmonella Indiana, Salmonella Saint-Paul, Salmonella Brandenburg.
11. The method of claim 10 , wherein the at least one attenuated Salmonella or the least one inactivated Salmonella of the Salmonella B group is Salmonella Typhimurium.
12. The method of claim 2 , wherein the at least one attenuated Salmonella or the at least one inactivated Salmonella is selected from the Salmonella D group.
13. The method of claim 12 , wherein the Salmonella D group comprises Salmonella Enteritidis, Salmonella Panama, Salmonella Dublin, Salmonella Gallinarum, Salmonella Pullorum.
14. The method of claim 13 , wherein the at least one attenuated Salmonella or the at least one inactivated Salmonella of the Salmonella D group is Salmonella Enteritidis.
15. The method of claim 1 :
wherein the at least one attenuated Salmonella is a Salmonella of D group, the at least one inactivated Salmonella is a Salmonella of B group,
further comprising at least one administration of Salmonella of D group between about 3 and about 10 weeks following the administration of the at least one inactivated Salmonella of B group.
16. The method of claim 14 , wherein the attenuated D group Salmonella bacteria are Salmonella Enteritidis, inactivated B group Salmonella bacteria are Salmonella Typhimurium and inactivated D group Salmonella bacteria are Salmonella Enteritidis.
17. The method of claim 1 , wherein the primo-administration and boost-administration are administered between 3 and 6 weeks apart.
18. The method of claim 2 , wherein the primo-administration and boost-administration are administered between 3 and 6 weeks apart.