Cycloalkyl-hydroxyl compounds and compositions for cholesterol management
The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, Syndrome X, thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
1. A compound having a structure selected from:
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable vehicle, excipient, or diluent.
3. The pharmaceutical composition comprising a compound of claim 1 further comprising a second therapeutic agent.
4. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable vehicle, excipient, or diluent which is administered in combination with a statin.
5. A compound according to claim 1 wherein the compound is represented by the formula
or a pharmaceutically acceptable salt thereof.
6. A compound according to claim 1 wherein the compound is represented by the formula
or a pharmaceutically acceptable salt thereof.
7. A compound according to claim 1 wherein the compound is represented by the formula
or a pharmaceutically acceptable salt thereof.
8. A compound according to claim 1 wherein the compound is represented by the formula
or a pharmaceutically acceptable salt thereof.
9. A compound according to claim 1 wherein the compound is represented by the formula
or a pharmaceutically acceptable salt thereof.
10. A compound according to claim 1 wherein the compound is represented by the formula
or a pharmaceutically acceptable salt thereof.
11. A compound according to claim 1 wherein the compound is represented by the formula
or a pharmaceutically acceptable salt thereof.
12. A compound according to claim 1 wherein the compound is represented by the formula
or a pharmaceutically acceptable salt thereof.
13. A compound according to claim 1 wherein the compound is represented by the formula
or a pharmaceutically acceptable salt thereof.
14. A compound according to claim 1 wherein the compound is represented by the formula
or a pharmaceutically acceptable salt thereof.
15. A compound according to claim 1 wherein the compound is represented by the formula
or a pharmaceutically acceptable salt thereof.
16. A compound according to claim 1 wherein the compound is represented by the formula
or a pharmaceutically acceptable salt thereof.
17. A compound according to claim 1 wherein the compound is represented by the formula
or a pharmaceutically acceptable salt thereof.
18. A compound according to claim 1 wherein the compound is represented by the formula
or a pharmaceutically acceptable salt thereof.
19. A compound according to claim 1 wherein the compound is represented by the formula
or a pharmaceutically acceptable salt thereof.
20. A compound according to claim 1 wherein the compound is represented by the formula
or a pharmaceutically acceptable salt thereof.
21. A compound according to claim 1 wherein the compound is represented by the formula
or a pharmaceutically acceptable salt thereof.