Composition and method for treatment of stomatitis
View Patent ↗A composition and a method effective in preventing or treating stomatitis are presented. The composition contains glutathione or a pharmaceutically acceptable salt thereof and/or orotic acid or a derivative thereof or a pharmaceutically acceptable salt thereof is provided.
1. A method for treatment of stomatitis, which method comprises administering a composition to a subject afflicted with stomatitis, wherein said composition is a chewable tablet, sublingual tablet, chewing gum, gummy candy, or drop which comprises (a) glutathione or a pharmaceutically acceptable salt of glutathione, and/or (b) free orotic acid or a pharmaceutically acceptable salt of orotic acid selected from the group consisting of sodium orotate, potassium orotate, magnesium orotate, calcium orotate, zinc orotate, ammonium orotate, tetramethyl ammonium orotate, morpholine orotate, and piperidine orotate, wherein one or more symptoms of stomatitis are improved in the subject.
2. The method according to claim 1 , wherein said glutathione is a reduced glutathione or oxidized glutathione.
3. The method according to claim 1 , wherein the composition comprises free orotic acid or zinc orotate.
4. The method according to claim 1 , wherein stomatitis is a result of radiation therapy or chemotherapy.
5. The method according to claim 1 , wherein said composition is administered as a medicine, food, or food additive.
6. The method according to claim 2 , wherein said glutathione is a reduced glutathione.
7. The method according to claim 2 , wherein said glutathione is an oxidized glutathione.
8. A method for treatment of stomatitis, which method comprises administering a composition to a subject afflicted with stomatitis, wherein said composition comprises free orotic acid or a pharmaceutically acceptable salt of orotic acid selected from the group consisting of sodium orotate, potassium orotate, magnesium orotate, calcium orotate, zinc orotate, ammonium orotate, tetramethyl ammonium orotate, morpholine orotate, and piperidine orotate, wherein one or more symptoms of stomatitis are improved in the subject.
9. The method of claim 8 , where the composition comprises free orotic acid or zinc orotate.
10. The method according to claim 1 , wherein stomatitis is a result of mechanical damage or poor oral hygiene.
11. A method for treatment of stomatitis resulting from radiation therapy, chemotherapy, mechanical damage, or poor oral hygiene, which method comprises administering a composition to a subject afflicted with stomatitis resulting from radiation therapy, chemotherapy, mechanical damage, or poor oral hygiene, wherein said composition comprises (a) glutathione or a pharmaceutically acceptable salt of glutathione, and/or (b) free orotic acid or a pharmaceutically acceptable salt of orotic acid selected from the group consisting of sodium orotate, potassium orotate, magnesium orotate, calcium orotate, zinc orotate, ammonium orotate, tetramethyl ammonium orotate, morpholine orotate, and piperidine orotate, wherein one or more symptoms of stomatitis resulting from radiation therapy, chemotherapy, mechanical damage, or poor oral hygiene are improved in the subject.
12. The method according to claim 11 , wherein said composition is a chewable tablet, sublingual tablet, chewing gum, gummy candy, or drop.