Nucleic acids encoding modified human immunodeficiency virus type 1 (HIV-1) group M consensus envelope glycoproteins
The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
1. A nucleic acid comprising a codon-optimized nucleotide sequence that encodes the protein encoded by the nucleic acid sequence of FIG. 29C (SEQ ID NO:37).
2. A vector comprising the nucleic acid according to claim 1 .
3. A composition comprising the nucleic acid according to claim 1 and a carrier.
4. A method of inducing an immune response in a mammal comprising administering to said mammal an amount of the nucleic acid according to claim 1 sufficient to effect said induction.
5. A nucleic acid comprising the nucleotide sequence set forth in FIG. 29C (SEQ ID NO:37).
6. A vector comprising the nucleic acid according to claim 5 .
7. A composition comprising the nucleic acid according to claim 5 and a carrier.
8. A method of inducing an immune response in a mammal comprising administering to said mammal an amount of the nucleic acid according to claim 5 sufficient to effect said induction.