Compositions and methods for modulating the immune system
View Patent ↗The present invention provides methods and compositions for the prophylaxis of blood cell disorders such as neutropenia, thrombocytopenia, lymphocytopenia, and anaemia. The invention provides methods wherein compositions comprising at least one cytokinin compound are administered either therapeutically or prophylactically. The invention further has utility in methods of DNA repair.
1. A method for the treatment and/or prophylaxis of blood cell depletion, the method comprising:
providing a therapeutically effective or prophylactically effective amount of oltipraz or a derivative, analogue, metabolite, prodrug or pharmaceutically acceptable salt thereof; and
administering same to a subject in need thereof.
2. The method as claimed in claim 1 wherein the blood cell depletion results in at least one condition selected from the group consisting of neutropenia, thrombocytopenia, lymphocytopenia and anaemia.
3. The method as claimed in claim 1 wherein the oltipraz metabolite is metabolite 3.
4. The method as claimed in claim 1 wherein oltipraz or the derivative, analogue, metabolite, prodrug or pharmaceutically acceptable salt thereof is formulated with carboxymethyl cellulose to form a combined medicament.
5. A pharmaceutical composition for use in the treatment of blood cell depletion, the composition comprising oltipraz in the form of metabolite 3 and a pharmaceutically acceptable diluent and/or carrier.
6. The pharmaceutical composition as claimed in claim 5 wherein the composition is formulated along with carboxymethyl cellulose.
7. A method for the treatment and/or prophylaxis of blood cell depletion, the method comprising:
providing a therapeutically or prophylactically effective amount of at least one cytokinin compound; and
administering same to a subject in need thereof.
8. The method as claimed in claim 7 wherein the cytokinin compound is N 6 isopentenyl adenosine or a derivative, analogue, metabolite, prodrug or pharmaceutically acceptable salt thereof.
9. The method as claimed in claim 8 wherein the N 6 isopentenyl adenosine or derivative, analogue, metabolite, prodrug or pharmaceutically acceptable salt thereof is formulated with carboxymethyl cellulose to form a combined medicament.
10. A combined pharmaceutical composition for the prevention and/or treatment and/or amelioration of a blood cell deficiency disorder, the composition comprising a cytokinin compound and a derivative or functionally equivalent analogue of oltipraz along with at least one pharmaceutically acceptable diluent, wherein the analogue or derivative of oltipraz is selected from the group consisting of 3H-1,2-dithiole-3-thione, sulforaphane, 5-(4-methoxyphenyl)-3H-1,2-dithiole-3-thione, ADT, ADO, 1,2-dithiole-3-thione, 1,2-dithiolane, 1,3-dithiole-2-thione and malotilate.
11. The composition as claimed in claim 10 wherein the cytokinin compound is N 6 isopentenyl adenosine or an analogue or a pharmaceutically acceptable salt thereof.
12. The composition as claimed in claim 10 wherein the cytokinin compound is N 6 benzyl adenosine or an analogue or pharmaceutically acceptable salt thereof.
13. A method of stimulating cellular DNA repair mechanisms in a subject in advance of or following exposure of the subject to radiation, the method comprising the steps of:
providing a therapeutically or prophylactically effective amount of a composition comprising oltipraz in the form of metabolite 3, and
administering the composition to the subject.
14. The method as claimed in claim 13 wherein the radiation exposure results from the subject undergoing travel in space.
15. The method as claimed in claim 7 further comprising the step of administering to the subject a therapeutically effective or prophylactically effective amount of oltipraz or a derivative, analogue, metabolite, prodrug or pharmaceutically acceptable salt thereof.
16. A method of treating and/or preventing radiation-induced immunosuppression, the method comprising the step of administering a therapeutically or prophylactically effective amount of N 6 isopentenyl adenosine to a subject in need thereof.
17. The composition as claimed in claim 10 wherein the blood cell deficiency disorder is selected from the group consisting of neutropenia, thrombocytopenia and anaemia.
18. A method for the treatment and/or prophylaxis of blood cell depletion, the method comprising:
providing a therapeutically effective or prophylactically effective amount of oltipraz in the form metabolite 3; and
administering same to a subject in need thereof.