Vector
A vector comprising a nucleotide sequence of interest (“NOI”) encoding a product of interest (“POI”) is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use the vector is capable of delivering the NOI and/or the POI to the tumor.
1. A vector comprising a nucleotide sequence coding for a protein consisting essentially of an antibody that binds 5T4, said antibody comprising 5T4 complementarity determining regions (CDRs) of the 5T4 ScFv antibody amino acid sequence encoded by SEQ ID NO:1 or CDRs of the 5T4 Sab antibody amino acid sequence encoded by SEQ ID NO:2.
2. The vector according to claim 1 , wherein the antibody is a 5T4 Fab, 5T4 Fv or 5T4 scFc fragment.
3. The vector according to claim 1 , wherein the antibody is a humanized antibody.
4. A vector comprising a nucleotide sequence coding for a protein consisting essentially of an antibody that binds 5T4, said antibody comprising 5T4 complementarity determining regions (CDRs) having the amino acid sequence of KASQSVSNDVA (SEQ ID NO:26), YTSSRYA (SEQ ID NO:27), QQDYNSPPT (SEQ ID NO:28), GYYMH (SEQ ID NO:29), RINPNNGVTLYNQKFKD (SEQ ID NO:30), and STMITNYVMDY (SEQ ID NO:31).
5. The vector according to claim 4 , wherein the antibody is a 5T4 Fab, 5T4 Fv or 5T4 scFc fragment.
6. The vector according to claim 4 , wherein the antibody is a humanized antibody.