Schizophrenia-related isoform of KCNH2 and development of antipsychotic drugs
View Patent ↗The invention is related to a novel primate specific brain isoform of the potassium channel KCNH2 and genetic association with risk for schizophrenia.
1. An isolated nucleic acid molecule encoding a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:5, SEQ ID NO:27 and SEQ ID NO:28.
2. The isolated nucleic acid molecule of claim 1 , wherein said nucleic acid encodes the polypeptide comprising the amino acid sequence of SEQ ID NO: 5.
3. The isolated nucleic acid molecule of claim 1 , wherein said nucleic acid encodes the polypeptide of SEQ ID NO: 27 or SEQ ID NO: 28.
4. An isolated nucleic acid molecule comprising a polynucleotide sequence of SEQ ID NO:3.
5. An isolated polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:5, SEQ ID NO:27 and SEQ ID NO:28.
6. The isolated polypeptide of claim 5 , wherein said polypeptide comprises the amino acid sequence of SEQ ID NO: 5.
7. The isolated polypeptide of claim 5 , wherein said polypeptide comprises the amino acid sequence of SEQ ID NO: 27 or SEQ ID NO: 28.
8. A recombinant vector comprising a nucleic acid molecule selected from the group consisting of:
i) a nucleic acid molecule comprising a polynucleotide sequence encoding a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:5, SEQ ID NO:27 and SEQ ID NO:28; and,
ii) a nucleic acid molecule comprising the polynucleotide sequence of SEQ ID NO:3.
9. A recombinant host cell comprising a recombinant vector comprising a nucleic acid molecule selected from the group consisting of:
i) a nucleic acid molecule comprising a polynucleotide sequence encoding a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:5, SEQ ID NO:27 and SEQ ID NO:28; and,
ii) a nucleic acid molecule comprising the polynucleotide sequence of SEQ ID NO:3.
10. A method of making a polypeptide selected from the group consisting of SEQ ID NO:5, SEQ ID NO:27 and SEQ ID NO:28 comprising culturing a host cell of claim 9 under conditions such that the polypeptide is expressed.