CHEC-7 a novel sPLA2 inhibitor
View Patent ↗The present invention relates to the discovery of a composition including a seven-amino acid peptide that promotes neuronal survival, inhibits inflammation, and is a potent inhibitor of sPL2A, and uses thereof.
1. An isolated neuron survival-promoting peptide, CHEC-7, consisting of the sequence of CHEASQC (SEQ ID NO: 3).
2. A pharmaceutical preparation comprising the neuron survival-promoting peptide of claim 1 , in a biologically acceptable carrier.
3. A kit for treating a neurodegenerative disorder or inflammatory disorder in a patient comprising:
a) an isolated CHEC-7 peptide consisting of the sequence of CHEASQC (SEQ ID NO: 3);
b) a pharmaceutical excipient; and optionally
c) a vehicle for administration, such as a syringe or catheter;
and instructional material.
4. The kit of claim 3 , wherein the kit further comprises a detectable label.