IP Library › Granted Patent US 8,110,551
Granted Patent B2
US 8,110,551 · App. 12/357,471 · Granted Feb 7, 2012

Cytolethal distending toxin and use thereof

Assignee: The Trustees of the University of Pennsylvania
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Quick Facts
Patent No.
US 8,110,551
App. No.
12/357,471
Granted
Feb 7, 2012
Kind
B2
Abstract

This invention relates to immunotoxins and their use. Specifically, the invention relates to compositions comprising Cdt toxins or their inhibitors and their use in methods for treating infectious and proliferative diseases.

Claims (4)

1. A method for inhibiting the proliferation of a lymphocyte cell the method comprising: contacting said cell with a CdtB toxin comprising the amino acid sequence as set forth in SEQ ID NO:3 having a mutation at amino acid position 163 of the CdtB toxin, thereby inhibiting the proliferation of said lymphocyte cell at its G2 phase.

2. The method of claim 1 , wherein said mutation is A163N or A163R.

3. The method of claim 1 , wherein said method further comprising contacting said cell with an agent capable of reducing the concentration of PI-3,4,5-triphosphate.

4. The method of claim 1 , wherein said CdtB toxin is derived from Actinobacillus actinomycetemcomitans.

Assignments (2)
CONFIRMATORY LICENSE Recorded Nov 9, 2022
From: UNIVERSITY OF PENNSYLVANIA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 061902/0237 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 31, 2009
From: SHENKER, BRUCE; BOESZE-BATTAGLIA, KATHLEEN
To: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Reel/Frame 022472/0093 →
Continuity (2)
Provisional Application 61006557 · Jan 22, 2008
Related Publication 20090202592A1 · Aug 13, 2009