8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
This invention relates to novel 8-aza-bicyclo[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
1. An 8-aza-bicyclo[3.2.1]octane derivative of Formula I:
any of its stereoisomers or any mixture of its stereoisomers, or a pharmaceutically acceptable salt thereof, wherein
R a represents a naphthyl group, which naphthyl group is substituted with —O—R b ; wherein R b presents hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl or alkynyl; and which naphthyl group is optionally further substituted with one or more substituents independently selected from the group consisting of: halo, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, amino, nitro, oxo, alkoxy, cycloalkoxy, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl and alkynyl.
2. The chemical compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R a represents
3. The chemical compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R a represents
4. The chemical compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R b presents hydrogen.
5. The chemical compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R b presents alkyl.
6. The chemical compound of claim 1 , which is
exo-3-(6-Methoxy-naphthalen-2-yloxy)-8-aza-bicyclo[3.2.1]octane;
exo-6-(8-Aza-bicyclo[3.2.1]oct-3-yloxy)-naphthalen-2-ol;
exo-3-(6-Ethoxy-naphthalen-2-yloxy)-8-aza-bicyclo[3.2.1]octane;
exo-3-(6-Isopropoxy-naphthalen-2-yloxy)-8-aza-bicyclo[3.2.1]octane;
exo-3-(7-Methoxy-naphthalen-2-yloxy)-8-aza-bicyclo[3.2.1]octane;
or a pharmaceutically acceptable salt thereof.
7. A pharmaceutical composition, comprising a therapeutically effective amount of a compound of claim 1 , any of its stereoisomers or any mixture of its stereoisomers, or a pharmaceutically acceptable salt thereof, together with at least one pharmaceutically acceptable carrier, excipient or diluent.