IP Library Granted Patent US 8,110,596
Granted Patent B2
US 8,110,596 · App. 11/991,406 · Granted Feb 7, 2012

Triprenyl phenol compound, process for production of triprenyl phenol compound, and thrombolysis enhancer

Assignee: Tokyo University of Agriculture and Technology TLO Co., Ltd.
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Quick Facts
Patent No.
US 8,110,596
App. No.
11/991,406
Granted
Feb 7, 2012
Kind
B2
Abstract

The present invention provides a triprenyl phenol compound represented by the following formula (II) and (III) and having a thrombolysis-enhancing activity, and an efficient method for producing the triprenyl phenol compound. In formula (II) and (III), R 1 represents an aromatic group having as a substituent or as a part of a substituent at least one member selected from the group consisting of a carboxyl group, a hydroxyl group, a sulfonic acid group and a secondary amino group, or an aromatic group which comprises a secondary amino group and may comprise nitrogen; R 4 in the general formula (III) represents an aromatic amino acid residue represented by the general formula (III-1) below; X represents —CHY—(CH 3 ) 2 Z; and Y and Z are respectively —H or —OH or together form a single bond: (III-1) wherein R 5 represents a hydroxyl group which may be present or absent; and n represents an integer of 0 or 1.

Claims (12)

1. A triprenyl phenol compound of the following formula (II) or (III):

wherein, in Formula (II), R 1 is an aromatic group having as a substituent or as a part of a substituent at least one group selected from the group consisting of a carboxyl group, a hydroxyl group, a sulfonic acid group and a secondary amino group,

X is —CHY—C(CH 3 ) 2 Z; and Y and Z are respectively —H or —OH, or together form a single bond;

wherein, in Formula (III), R 4 is an aromatic amino acid residue of the following formula (III-1) (provided that tyrosine residue and phenylalanine residue are excluded); X is —CHY—C(CH 3 ) 2 Z; and Y and Z are respectively —H or —OH, or together form a single bond,

wherein R 5 is a substituent which may be present or absent and which is selected from the group consisting of a hydroxyl group, a carboxyl group and an alkyl group having 1 to 5 carbon atoms, and wherein n represents an integer of 0 or 1.

2. The triprenyl phenol compound of claim 1 , wherein the triprenyl phenol compound is of Formula (II).

3. The triprenyl phenol compound of claim 2 , wherein the aromatic group is of the following formula (II-1):

wherein R 2 and R 3 respectively are a carboxyl group, a hydroxyl group or a sulfonic acid group, or are joined together to form a cyclic group containing a secondary amino group.

4. The triprenyl phenol compound of claim 2 , wherein the aromatic group is selected from the following:

5. The triprenyl phenol compound of claim 1 , wherein the triprenyl phenol compound is of Formula (III).

6. The triprenyl phenol compound of claim 5 , wherein R 4 in Formula (III) is selected from the following:

7. A thrombolysis enhancer comprising the triprenyl phenol compound of claim 1 as an active ingredient, and an excipient or a solvent.

Assignments (5)
CHANGE OF NAME Recorded Dec 4, 2024
From: JI XING PHARMACEUTICALS HONG KONG LIMITED
To: CORXEL PHARMACEUTICALS HONG KONG LIMITED
Reel/Frame 069491/0774 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 30, 2024
From: BIOGEN MA INC.
To: JI XING PHARMACEUTICALS HONG KONG LIMITED
Reel/Frame 066379/0891 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 20, 2021
From: TMS CO., LTD.
To: BIOGEN MA INC.
Reel/Frame 057534/0699 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 23, 2017
From: TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY TLO CO., LTD.
To: TMS CO., LTD.
Reel/Frame 042082/0818 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 3, 2008
From: HASUMI, KEIJI; KITANO, YOSHIKAZU; OHISHI, HIDEO; KOIDE, HARUKI; HASEGAWA, KEIKO; NARASAKI, RITSUKO
To: TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY TLO CO., LTD.
Reel/Frame 021197/0373 →
Priority Claims (2)
JP 2006-086434 · Mar 27, 2006 · national
JP 2006-324870 · Nov 30, 2006 · national
Continuity (1)
Related Publication 20090216028A1 · Aug 27, 2009