MART-1 T cell receptors
View Patent ↗T-cell receptors that recognize MART-1 antigen are provided. The TCRs can be used, for example, to treat patients suffering from melanoma.
1. An isolated polypeptide comprising an amino acid sequence with at least 95% sequence identity to SEQ ID NO: 3, wherein the variable region of the polypeptide consists of SEQ ID NO: 4.
2. The isolated polypeptide of claim 1 , wherein the polypeptide comprises the amino acid sequence of SEQ ID NO: 3.
3. A transfected cell comprising:
a T-cell receptor comprising an α subunit with at least 95% sequence identity to SEQ ID NO: 3 and a β subunit with at least 95% sequence identity to SEQ ID NO:7, wherein the variable region of the α subunit consists of SEQ ID NO: 4, and wherein the variable region of the β subunit consists of SEQ ID NO: 8.
4. A T-cell receptor, comprising:
an α subunit; and
a β subunit,
wherein the α subunit comprises an amino acid sequence with at least 95% sequence identity to SEQ ID NO: 3 and the β subunit comprises an amino acid with at least 95% sequence identity to SEQ ID NO:7, wherein the variable region of the α subunit consists of SEQ ID NO: 4, and wherein the variable region of the β subunit consists of SEQ ID NO: 8.
5. The isolated polypeptide of claim 1 , wherein the polypeptide comprises an amino acid sequence with at least 99% sequence identity to SEQ ID NO: 3.
6. The isolated polypeptide of claim 1 , wherein the polypeptide comprises the amino acid sequence of SEQ ID NO: 3.
7. The transfected cell of claim 3 , wherein the α subunit has at least 99% sequence identity to SEQ ID NO: 3.
8. The transfected cell of claim 3 , wherein the α subunit consists of the amino acid sequence of SEQ ID NO: 3.
9. The transfected cell of claim 3 , wherein the β subunit has at least 99% sequence identity to SEQ ID NO:7.
10. The transfected cell of claim 3 , wherein the β subunit consists of the amino acid sequence of SEQ ID NO: 7.
11. The T-cell receptor of claim 4 , wherein the α subunit has at least 99% sequence identity to SEQ ID NO: 3.
12. The T-cell receptor of claim 4 , wherein the α subunit consists of the amino acid sequence of SEQ ID NO: 3.
13. The T-cell receptor of claim 4 , wherein the β subunit has at least 99% sequence identity to SEQ ID NO:7.
14. The T-cell receptor of claim 4 , wherein the β subunit consists of the amino acid sequence of SEQ ID NO: 7.